Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Thioacetazone [INN:BAN]
RN: 104-06-3
UNII: MMG78X7SSR
InChIKey: SRVJKTDHMYAMHA-WUXMJOGZSA-N

Note

  • A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217)

Molecular Formula

  • C10-H12-N4-O-S

Molecular Weight

  • 236.2978
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antitubercular Agents
  • Drug / Therapeutic Agent
  • Mutation Data
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Results Name

  • Thioacetazone [INN:BAN]

Name of Substance

  • Amithiozone
  • Thiacetazone
  • Thioacetazone
  • Thioacetazone [INN:BAN]

MeSH Heading

  • Thioacetazone

Synonyms

  • 4'-Formylacetanilide thiosemicarbazone
  • 4-14-00-00075 (Beilstein Handbook Reference)
  • 4-Acetylaminobenzaldehyde thiosemicarbazone
  • 4207 RP
  • A 4081
  • AI3-18591
  • Aktivan
  • Ambathizon
  • Amithiozone
  • Amitiozon
  • Antib
  • Benthiozone
  • Benzothiozane
  • Benzothiozon
  • Berculon A
  • Berkazon
  • BRN 2810335
  • CBC 903150
  • Conteben
  • Diasan
  • Diazan
  • Domagk's T.B.1 conteben
  • Domakol
  • EINECS 203-170-6
  • Ilbion
  • Livazone
  • Magk's T.B.1 conteben
  • Mivizon
  • Myvizone
  • Neotibil
  • Neustab
  • Novakol
  • NSC 3550
  • Nuclon argentinian
  • p-Acetamidobenzaldehyde thiosemicarbazone
  • p-Acetaminobenzylidenethiosemicarbazone
  • p-Acetoaminobenzaldehyde thiosemicarbazone
  • p-Acetylaminobenzadehyde thiosemicarbazone
  • p-Formylacetanilide-3-thiosemicarbazone
  • Panrone
  • Parazone
  • RP 4207
  • SDT 1041
  • Seroden
  • Siocarbazone
  • SQ 2321
  • TB I
  • TB I (Bayer)
  • TB I/698
  • TBI
  • Tebalon
  • Tebecure
  • Tebemar
  • Tebesone I
  • Tebethion
  • Tebethione
  • Tebezon
  • Thiacetazone
  • Thiacetone
  • Thiacetozone
  • Thibon
  • Thibone
  • Thioacetazon
  • Thioacetazone
  • Thioacetazonum
  • Thioacetazonum [INN-Latin]
  • Thioazetazone
  • Thiocarbazil
  • Thiomicid
  • Thionicid
  • Thioparamizon
  • Thioparamizone
  • Thiosemicarbarzone
  • Thiosemicarbazone
  • Thiosemicarbazone (pharmaceutical)
  • Thiotebesin
  • Thiotebezin
  • Thiotebicina
  • Thizone
  • Tiacetazon
  • Tibicur
  • Tibizan
  • Tibon
  • Tibone
  • Tioacetazon
  • Tioacetazona
  • Tioacetazona [INN-Spanish]
  • Tioatsetazon
  • Tiobicina
  • Tiocarone
  • Tiosecolo
  • Tubercazon
  • Tubigal
  • Tubin
  • UNII-MMG78X7SSR

Systematic Names

  • 4'-Formylacetanilide thiosemicarbazone
  • Acetamide, N-(4-(((aminothioxomethyl)hydrazono)methyl)phenyl)-
  • Acetanilide, 4'-formyl-, 4'-(thiosemicarbazone)
  • Thioacetazone

Registry Numbers

CAS Registry Number

  • 104-06-3

FDA UNII

  • MMG78X7SSR

System Generated Number

  • 0000104063

Structure Descriptors

InChI

1S/C10H12N4OS/c1-7(15)13-9-4-2-8(3-5-9)6-12-14-10(11)16/h2-6H,1H3,(H,13,15)(H3,11,14,16)/b12-6+

InChIKey

SRVJKTDHMYAMHA-WUXMJOGZSA-N

Smiles

c1(ccc(\C=N\NC(N)=S)cc1)NC(C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 950mg/kg (950mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: COMA
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 144, Pg. 1310, 1950.
mouse LD50 subcutaneous 1gm/kg (1000mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 2, Pg. 764, 1950.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 225 dec deg C   EXP
log P (octanol-water) 1.090 (none)   EST
Water Solubility 88 mg/L 20 EXP
Atmospheric OH Rate Constant 1.01E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.