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Substance Name: Tussilagone
RN: 104012-37-5
UNII: 95N0GBB2SX
InChIKey: CFUPNMDNSQIWBB-ACCKDKKQSA-N

Note

  • An oplopanone type saturated indene sesquiterpene; platelet activating factor antagonist.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C23-H34-O5

Molecular Weight

  • 390.517
 
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Names and Synonyms

Name of Substance

  • Tussilagone

Synonyms

  • (7R,14R)-14-Acetoxy-7-((2'E)-3'-methylpent-2'-enoyloxy)-oplopanone
  • Tussilagone
  • UNII-95N0GBB2SX

Systematic Name

  • 2-Pentenoic acid, 3-methyl-, 1-(1-(acetyloxy)ethyl)octahydro-4-methylene-7-(1-methylethyl)-2-oxo-1H-inden-5-yl ester, (1S-(1-alpha(S*),3a-beta,5-beta(E),7-alpha,7a-alpha))-

Registry Numbers

CAS Registry Number

  • 104012-37-5

FDA UNII

  • 95N0GBB2SX

System Generated Number

  • 0104012375

Structure Descriptors

InChI

1S/C23H34O5/c1-8-13(4)9-21(26)28-20-11-17(12(2)3)23-18(14(20)5)10-19(25)22(23)15(6)27-16(7)24/h9,12,15,17-18,20,22-23H,5,8,10-11H2,1-4,6-7H3/b13-9+/t15?,17-,18-,20+,22+,23-/m0/s1

InChIKey

CFUPNMDNSQIWBB-ACCKDKKQSA-N

Smiles

C(\C=C(\CC)C)(=O)O[C@H]1C([C@@H]2CC([C@H]([C@H]2[C@@H](C1)C(C)C)[C@@H](C)OC(=O)C)=O)=C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 28900ug/kg (28.9mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
General Pharmacology. Vol. 19, Pg. 261, 1988.