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Substance Name: Eprazinone hydrochloride [JAN]
RN: 10402-53-6
UNII: 394X1L8I9Y
InChIKey: BPMQVOKMMQFZGV-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H32-N2-O2.2Cl-H

Molecular Weight

  • 453.451
 
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Names and Synonyms

Name of Substance

  • Eprazinone dihydrochloride
  • Eprazinone hydrochloride [JAN]

Synonyms

  • 1-(2-Benzoylpropyl)-2-(2-ethoxy-2-phenylethyl)piperazine dihydrochloride
  • 1-(2-Phenyl-2-ethoxy)ethyl-4-(2-benzyloxy)propylpiperazine dihydrochloride
  • 2-(4-(beta-Ethoxyphenethyl)-1-piperazinylmethyl)propiophenone dihydrochloride
  • 3-(4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-1-propanone dihydrochloride
  • 3-(4-(beta-Ethoxyphenethyl)-1-piperazinyl)-2-methyl-1-propiophenone dihydrochloride
  • 746 CE
  • Eftapan
  • EINECS 233-872-8
  • Eprazinone dihydrochloride
  • Eprazinone HCl
  • Eprazinone hydrochloride
  • Mucitux
  • NSC 317935
  • Resplen
  • UNII-394X1L8I9Y

Systematic Names

  • 1-Propanone, 3-(4-(2-ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-, dihydrochloride
  • 3-(4-(beta-Ethoxyphenethyl)-1-piperazinyl)-2-methylpropiophenone dihydrochloride
  • Propiophenone, 2-(4-(beta-ethoxyphenethyl)-1-piperazinyl)methyl-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 10402-53-6

FDA UNII

  • 394X1L8I9Y

System Generated Number

  • 0010402536

Molecular Formulas

Molecular Formula

  • C24-H32-N2-O2.2Cl-H

Molecular Formula Fragments

  • C24-H32-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C24H32N2O2.2ClH/c1-3-28-23(21-10-6-4-7-11-21)19-26-16-14-25(15-17-26)18-20(2)24(27)22-12-8-5-9-13-22;;/h4-13,20,23H,3,14-19H2,1-2H3;2*1H

InChIKey

BPMQVOKMMQFZGV-UHFFFAOYSA-N

Smiles

c1([C@@H](CN2CCN(C[C@@H](C(c3ccccc3)=O)C)CC2)OCC)ccccc1.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 116mg/kg (116mg/kg)   Beijing Yixueyuan Xuebao. Journal of Peking Medical College. Vol. 13(2), Pg. 98, 1981.
mouse LD50 intravenous 20mg/kg (20mg/kg)   Beijing Yixueyuan Xuebao. Journal of Peking Medical College. Vol. 13(2), Pg. 98, 1981.
mouse LD50 oral 286mg/kg (286mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
mouse LD50 subcutaneous 300mg/kg (300mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 314, 1968.
rat LD50 intraperitoneal 191mg/kg (191mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
rat LD50 oral 763mg/kg (763mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
rat LD50 subcutaneous 238mg/kg (238mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.