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Substance Name: Mitindomide [USAN:INN]
RN: 10403-51-7
UNII: DK61ZER6T7
InChIKey: DRCJGCOYHLTVNR-ZUIZSQJWSA-N

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent

Molecular Formula

  • C14-H12-N2-O4

Molecular Weight

  • 272.259
 
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Names and Synonyms

Name of Substance

  • Mitindomide
  • Mitindomide [USAN:INN]

Synonyms

  • (1R*,2S*,3R*,4S*,5R*,6S*,7S*,8R*)-Tricyclo(4.2.2.0(sup 2,5))dec-9-ene-3,4,7,8-tetracarboxylic 3,4:7,8-diimide
  • 1alpha,6alpha-Tricyclo(4.2.2.0(2,5))dec-9-en-3,4,7,8-bis(dicarboximid)
  • 4,8-Ethenopyrrolo(3',4':3,4)cyclobut(1,2-f)isoindole-1,3,5,7(2H,6H)-tetrone, 3a,3b,4,4a,7a,8,8a,8b-octahydro-, (3aalpha,3bbeta,4alpha,4abeta,7abeta,8alpha,8abeta,8balpha)-
  • 4,8-Ethenopyrrolo(3',4':3,4)cyclobut(1,2-f)isoindole-1,3,5,7(2H,6H)tetrone, octahydro-
  • Benzenebismaleimide adduct
  • BRN 5604909
  • CCRIS 832
  • Mitindomida
  • Mitindomida [Spanish]
  • Mitindomide
  • Mitindomidum
  • Mitindomidum [Latin]
  • NSC 284356
  • Tricyclo(4.2.2.0(2,5))dec-9-en-3,4,7,8-tetracarboxulic 3,4,7,8-diimide
  • Tricyclodecenetetracarboxydiimide
  • UNII-DK61ZER6T7

Systematic Names

  • 4,8-Ethenopyrrolo(3',4':3,4)cyclobut(1,2-f)isoindole-1,3,5,7(2H,6H)-tetrone, 3a,3b,4,4a,7a,8,8a,8b-octahydro- (9CI)
  • 4,8-Ethenopyrrolo(3',4':3,4)cyclobut(1,2-f)isoindole-1,3,5,7(2H,6H)-tetrone, 3a,3b,4,4a,7a,8,8a,8b-octahydro-, (3aalpha,3bbeta,4alpha,4abeta,7abeta,8alpha,8abeta,8balpha)-
  • Mitindomide
  • Tricyclo(4.2.2.0(sup 2,5))-dec-9-ene-3,4,7,8-tetracarboxylic(3,4,:7,8)diimide

Registry Numbers

CAS Registry Number

  • 10403-51-7

FDA UNII

  • DK61ZER6T7

System Generated Number

  • 0010403517

Structure Descriptors

InChI

1S/C14H12N2O4/c17-11-7-3-1-2-4(8(7)12(18)15-11)6-5(3)9-10(6)14(20)16-13(9)19/h1-10H,(H,15,17,18)(H,16,19,20)/t3-,4+,5+,6-,7-,8+,9-,10+

InChIKey

DRCJGCOYHLTVNR-ZUIZSQJWSA-N

Smiles

N1C(=O)[C@@H]2[C@H]3[C@H]4[C@@H]([C@@H](C=C3)[C@H]2C1=O)[C@@H]1C(NC([C@H]41)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 5gm/kg (5000mg/kg)   Pharmaceutical Chemistry Journal Vol. 25, Pg. 38, 1991.
mouse LD oral > 5gm/kg (5000mg/kg)   Pharmaceutical Chemistry Journal Vol. 25, Pg. 38, 1991.
mouse LD50 intravenous 193mg/kg (193mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,