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Substance Name: Trospium chloride [USAN:USP:INN:BAN:JAN]
RN: 10405-02-4
UNII: 1E6682427E
InChIKey: RVCSYOQWLPPAOA-QKYUOBHYSA-M

Molecular Formulas

  • C25-H30-Cl-N-O3
  • C25-H30-N-O3.Cl

Molecular Weight

  • 427.969
 

Classification Codes

  • Analgesics
  • Autonomic Agents
  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Human Data
  • Muscarinic Antagonists
  • Neurotransmitter Agents
  • Parasympatholytics
  • Peripheral Nervous System Agents
  • Sensory System Agents
  • Treatment of Urinary Incontinence
  • Urological Agents

Names and Synonyms

Name of Substance

  • Trospium chloride
  • Trospium chloride [USAN:USP:INN:BAN:JAN]

Synonyms

  • 3alpha-Hydroxyspiro(1alphaH,5alphaH-nortropane-8,1'-pyrrolidinium) chloride benzilate
  • 8-alpha-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride
  • AS Xvii
  • Azoniaspiro Compound XVII
  • Azoniaspiro(3-alpha-benziloyloxy-nortropan-8,1'-pyrrolidine)-chloride
  • Chlorure de trospium
  • Chlorure de trospium [INN-French]
  • Cloruro de trospio
  • Cloruro de trospio [INN-Spanish]
  • EINECS 233-875-4
  • IP631
  • Keptan
  • Relaspium
  • Sanctura
  • Sanctura XR
  • Santura
  • Spasmex
  • Spasmo 3
  • Spasmo-lyt
  • Spiro (8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-((hydroxydiphenylacetyl)oxy)-, chloride, (1alpha, 3beta, 5alpha)
  • Trospii chloridum
  • Trospii chloridum [INN-Latin]
  • Trospium
  • Trospium chloride
  • Trospium Cl
  • UNII-1E6682427E
  • Uraplex

Systematic Names

  • 3alpha-Hydroxyspiro(1alphaH,5alphaH-nortropane-8,1'-pyrrolidinium) chloride benzilate
  • Spiro(1-alpha-H,5-alpha-H-nortropane-8,1'-pyrrolidinium), 3-alpha-hydroxy-, chloride, benzilate
  • Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium, 3-((hydroxydiphenylacetyl)oxy)-, chloride, (1alpha,3beta,5alpha)-
  • Trospium chloride

Registry Numbers

CAS Registry Number

  • 10405-02-4

FDA UNII

  • 1E6682427E

Other Registry Number

  • 1001323-19-8

System Generated Number

  • 0010405024

Molecular Formulas

Molecular Formulas

  • C25-H30-Cl-N-O3
  • C25-H30-N-O3.Cl

Molecular Formula Fragments

  • C25-H30-N-O3
  • Cl
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23+;

InChIKey

RVCSYOQWLPPAOA-QKYUOBHYSA-M

Smiles

[Cl-].OC(C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]23CCCC3)(c4ccccc4)c5ccccc5

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo subcutaneous 160mg/kg (160mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: NAUSEA OR VOMITING		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
man TDLo oral 2571ug/kg (2.571mg/kg) AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE		 Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 461, 1993.
mouse LD50 intraperitoneal 50mg/kg (50mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
mouse LD50 intravenous 11200ug/kg (11.2mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
mouse LD50 oral 812mg/kg (812mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
mouse LD50 subcutaneous 203mg/kg (203mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
rabbit LDLo intravenous 20mg/kg (20mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
rabbit LDLo oral 3200mg/kg (3200mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
rat LD50 intraperitoneal 97700ug/kg (97.7mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
rat LD50 intravenous 15500ug/kg (15.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
rat LD50 oral 1510mg/kg (1510mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
rat LD50 subcutaneous 707mg/kg (707mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974.
rat LDLo intraduodenal 500mg/kg (500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1037, 1975.