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Substance Name: Trospium chloride [USAN:USP:INN:BAN:JAN]
RN: 10405-02-4
UNII: 1E6682427E
InChIKey: RVCSYOQWLPPAOA-QKYUOBHYSA-M
Molecular Formulas
- C25-H30-Cl-N-O3
- C25-H30-N-O3.Cl
Molecular Weight
- 427.969
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Analgesics
- Autonomic Agents
- Central Nervous System Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Drug / Therapeutic Agent
- Human Data
- Muscarinic Antagonists
- Neurotransmitter Agents
- Parasympatholytics
- Peripheral Nervous System Agents
- Sensory System Agents
- Treatment of Urinary Incontinence
- Urological Agents
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Names and Synonyms
Name of Substance
- Trospium chloride
- Trospium chloride [USAN:USP:INN:BAN:JAN]
Synonyms
- 3alpha-Hydroxyspiro(1alphaH,5alphaH-nortropane-8,1'-pyrrolidinium) chloride benzilate
- 8-alpha-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride
- AS Xvii
- Azoniaspiro Compound XVII
- Azoniaspiro(3-alpha-benziloyloxy-nortropan-8,1'-pyrrolidine)-chloride
- Chlorure de trospium
- Chlorure de trospium [INN-French]
- Cloruro de trospio
- Cloruro de trospio [INN-Spanish]
- EINECS 233-875-4
- IP631
- Keptan
- Relaspium
- Sanctura
- Sanctura XR
- Santura
- Spasmex
- Spasmo 3
- Spasmo-lyt
- Spiro (8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-((hydroxydiphenylacetyl)oxy)-, chloride, (1alpha, 3beta, 5alpha)
- Trospii chloridum
- Trospii chloridum [INN-Latin]
- Trospium
- Trospium chloride
- Trospium Cl
- UNII-1E6682427E
- Uraplex
Systematic Names
- 3alpha-Hydroxyspiro(1alphaH,5alphaH-nortropane-8,1'-pyrrolidinium) chloride benzilate
- Spiro(1-alpha-H,5-alpha-H-nortropane-8,1'-pyrrolidinium), 3-alpha-hydroxy-, chloride, benzilate
- Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium, 3-((hydroxydiphenylacetyl)oxy)-, chloride, (1alpha,3beta,5alpha)-
- Trospium chloride
Registry Numbers
CAS Registry Number
- 10405-02-4
FDA UNII
- 1E6682427E
Other Registry Number
- 1001323-19-8
System Generated Number
- 0010405024
Molecular Formulas
Molecular Formulas
- C25-H30-Cl-N-O3
- C25-H30-N-O3.Cl
Molecular Formula Fragments
- C25-H30-N-O3
- Cl
- COMPONENT
Structure Descriptors
InChI
1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23+;InChIKey
RVCSYOQWLPPAOA-QKYUOBHYSA-MSmiles
c1ccc(cc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | subcutaneous | 160mg/kg (160mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
man | TDLo | oral | 2571ug/kg (2.571mg/kg) | AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 461, 1993. |
mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
mouse | LD50 | intravenous | 11200ug/kg (11.2mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
mouse | LD50 | oral | 812mg/kg (812mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
mouse | LD50 | subcutaneous | 203mg/kg (203mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
rabbit | LDLo | intravenous | 20mg/kg (20mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
rabbit | LDLo | oral | 3200mg/kg (3200mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
rat | LD50 | intraperitoneal | 97700ug/kg (97.7mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
rat | LD50 | intravenous | 15500ug/kg (15.5mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
rat | LD50 | oral | 1510mg/kg (1510mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
rat | LD50 | subcutaneous | 707mg/kg (707mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 199, 1974. |
rat | LDLo | intraduodenal | 500mg/kg (500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1037, 1975. |