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Substance Name: Bisoprolol fumarate [USAN:USP:JAN]
RN: 104344-23-2
UNII: UR59KN573L
InChIKey: VMDFASMUILANOL-WXXKFALUSA-N
Note
- A cardioselective beta-1-adrenergic blocker. It is effective in the management of hypertension and angina pectoris.
Molecular Formula
- C18-H31-N-O4.1/2C4-H4-O4
Molecular Weight
- 766.963
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antihypertensive (beta-Blocker)
- Drug / Therapeutic Agent
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Bisoprolol fumarate [USAN:USP:JAN]
Synonyms
- (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt)
- (+-)-1-(p-((2-Isopropoxyethoxy)methyl)phenoxy)-3-isopropylamino-2-propanol hemifumarate
- 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butenedioate (2:1) (salt)
- Biso-Puren
- Bisobloc
- Bisomerck
- Bisoprolol fumarate
- Bisoprolol hemifumarate
- CL 297,939
- Concor
- Concor Plus Forte
- Detensiel
- Emcor
- EMD 33512
- Emvoncor
- Eurtadal
- Fondril
- Godal
- Isoten
- Maintate
- Monocor
- NSC 759181
- Soprol
- TA-4708
- UNII-UR59KN573L
- Zabesta
- Zebeta
Systematic Name
- 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butenedioate (2:1) (salt)
Registry Numbers
CAS Registry Number
- 104344-23-2
FDA UNII
- UR59KN573L
System Generated Number
- 0104344232
Molecular Formulas
Molecular Formula
- C18-H31-N-O4.1/2C4-H4-O4
Molecular Formula Fragments
- C18-H31-N-O4
- C4-H4-O4
- COMPONENT
Structure Descriptors
InChI
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+InChIKey
VMDFASMUILANOL-WXXKFALUSA-NSmiles
CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | oral | 40mg/kg (40mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2321, 1989. |
mouse | LD50 | intravenous | 111mg/kg (111mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
mouse | LD50 | oral | 678mg/kg (678mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
rat | LD50 | intravenous | 39mg/kg (39mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
rat | LD50 | oral | 940mg/kg (940mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |