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Substance Name: Bisoprolol fumarate [USAN:USP:JAN]
RN: 104344-23-2
UNII: UR59KN573L
InChIKey: VMDFASMUILANOL-WXXKFALUSA-N

Note

  • A cardioselective beta-1-adrenergic blocker. It is effective in the management of hypertension and angina pectoris.

Molecular Formula

  • C18-H31-N-O4.1/2C4-H4-O4

Molecular Weight

  • 766.963
 

Classification Codes

  • Antihypertensive (beta-Blocker)
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Bisoprolol fumarate [USAN:USP:JAN]

Synonyms

  • (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt)
  • (+-)-1-(p-((2-Isopropoxyethoxy)methyl)phenoxy)-3-isopropylamino-2-propanol hemifumarate
  • 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butenedioate (2:1) (salt)
  • Biso-Puren
  • Bisobloc
  • Bisomerck
  • Bisoprolol fumarate
  • Bisoprolol hemifumarate
  • CL 297,939
  • Concor
  • Concor Plus Forte
  • Detensiel
  • Emcor
  • EMD 33512
  • Emvoncor
  • Eurtadal
  • Fondril
  • Godal
  • Isoten
  • Maintate
  • Monocor
  • Soprol
  • TA-4708
  • UNII-UR59KN573L
  • Zabesta
  • Zebeta

Systematic Name

  • 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butenedioate (2:1) (salt)

Registry Numbers

CAS Registry Number

  • 104344-23-2

FDA UNII

  • UR59KN573L

System Generated Number

  • 0104344232

Molecular Formulas

Molecular Formula

  • C18-H31-N-O4.1/2C4-H4-O4

Molecular Formula Fragments

  • C18-H31-N-O4
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+

InChIKey

VMDFASMUILANOL-WXXKFALUSA-N

Smiles

C(=C\C(=O)O)\C(O)=O.c1c(ccc(COCCOC(C)C)c1)OC[C@@H](O)CNC(C)C.c1cc(ccc1OC[C@@H](CNC(C)C)O)COCCOC(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 40mg/kg (40mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2321, 1989.
mouse LD50 intravenous 111mg/kg (111mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989.
mouse LD50 oral 678mg/kg (678mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR		 Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989.
rat LD50 intravenous 39mg/kg (39mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989.
rat LD50 oral 940mg/kg (940mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989.