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Substance Name: Quifenadine hydrochloride
RN: 10447-38-8
UNII: 6WSK4828LL
InChIKey: MVCBFPDJWSQMNY-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H23-N-O.Cl-H

Molecular Weight

  • 329.869
 
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Names and Synonyms

Name of Substance

  • Quifenadine hydrochloride

Synonyms

  • 1-Azabicyclo(2.2.2)octane-3-methanol, alpha,alpha-diphenyl-, hydrochloride
  • alpha,alpha-Diphenyl-3-quinuclidinemethanol, hydrochloride
  • Fencarol
  • Fenkarol
  • Phencarol
  • Quifenadine hydrochloride
  • Quinuclidyl-3-diphenylcarbinol hydrochloride
  • UNII-6WSK4828LL

Systematic Name

  • 3-Quinuclidinemethanol, alpha,alpha-diphenyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 10447-38-8

FDA UNII

  • 6WSK4828LL

Related Registry Number

  • 10447-39-9 (Parent)

System Generated Number

  • 0010447388

Molecular Formulas

Molecular Formula

  • C20-H23-N-O.Cl-H

Molecular Formula Fragments

  • C20-H23-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H23NO.ClH/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21;/h1-10,16,19,22H,11-15H2;1H

InChIKey

MVCBFPDJWSQMNY-UHFFFAOYSA-N

Smiles

C1CC2[C@@H](CN1CC2)C(c1ccccc1)(O)c1ccccc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 860mg/kg (860mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR DILATION

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE
Farmakologiya i Toksikologiya Vol. 43, Pg. 148, 1980.
mouse LD50 intravenous 62mg/kg (62mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Russian Pharmacology and Toxicology Vol. 40, Pg. 42, 1977.
mouse LD50 oral 370mg/kg (370mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Russian Pharmacology and Toxicology Vol. 40, Pg. 42, 1977.
rat LD50 oral 440mg/kg (440mg/kg)   Russian Pharmacology and Toxicology Vol. 40, Pg. 42, 1977.