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Substance Name: Trapencaine [INN]
RN: 104485-01-0
UNII: 6H10WF5D0H
InChIKey: HVYGHQWGUABUST-NHCUHLMSSA-N

Molecular Formula

  • C22-H34-N2-O3

Molecular Weight

  • 374.5216
 

Classification Codes

  • Anesthetics
  • Anesthetics, Local
  • Anti-Ulcer Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Pentacaine
  • Trapencaine [INN]

Synonyms

  • CCRIS 3900
  • Pentacaine
  • Pentakain
  • Pentakain [Czech.]
  • trans-(+-)-2-(1-Pyrrolidinyl)cyclohexyl (3-(pentyloxy)phenyl)carbamate
  • Trapencaina
  • Trapencaina [INN-Spanish]
  • Trapencaine
  • Trapencainum
  • Trapencainum [INN-Latin]
  • UNII-6H10WF5D0H

Systematic Names

  • (+-)-trans-2-(1-Pyrrolidinyl)cyclohexyl m-(pentyloxy)carbanilate
  • Carbamic acid, (3-(pentyloxy)phenyl)-, 2-(1-pyrrolidinyl)cyclohexyl ester, trans-(+-)-
  • Pentacaine

Registry Numbers

CAS Registry Number

  • 104485-01-0

FDA UNII

  • 6H10WF5D0H

Other Registry Number

  • 76875-69-9

System Generated Number

  • 0104485010

Structure Descriptors

InChI

1S/C22H34N2O3/c1-2-3-8-16-26-19-11-9-10-18(17-19)23-22(25)27-21-13-5-4-12-20(21)24-14-6-7-15-24/h9-11,17,20-21H,2-8,12-16H2,1H3,(H,23,25)/t20-,21-/m1/s1

InChIKey

HVYGHQWGUABUST-NHCUHLMSSA-N

Smiles

CCCCCOc1cccc(c1)NC(=O)O[C@@H]2CCCC[C@H]2N3CCCC3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 58mg/kg (58mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
guinea pig LD50 subcutaneous 105mg/kg (105mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
mouse LD50 intraperitoneal 56mg/kg (56mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
mouse LD50 intravenous 10300ug/kg (10.3mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
mouse LD50 oral 790mg/kg (790mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
mouse LD50 subcutaneous 122mg/kg (122mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
rabbit LD50 intraperitoneal > 60mg/kg (60mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
rabbit LD50 intravenous 2950ug/kg (2.95mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
rat LD50 intraperitoneal 70mg/kg (70mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
rat LD50 intravenous 11800ug/kg (11.8mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
rat LD50 oral 1030mg/kg (1030mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.
rat LD50 subcutaneous 283mg/kg (283mg/kg)   Farmaceuticky Obzor. Pharmaceutical Review. Vol. 45, Pg. 355, 1976.