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Substance Name: Bromperidol [USAN:INN:BAN:JAN]
RN: 10457-90-6
UNII: LYH6F7I22E
InChIKey: RKLNONIVDFXQRX-UHFFFAOYSA-N

Note

  • Bromine-substituted for chlorine in haloperidol.

Molecular Formula

  • C21-H23-Br-F-N-O2

Molecular Weight

  • 420.3197
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Bromperidol
  • Bromperidol [USAN:INN:BAN:JAN]

Synonyms

  • 1-Butanone, 4-(4-(4-bromophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-
  • 4-(4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone
  • 4-(4-(4-Bromophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
  • 4-(4-(p-Bromophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
  • 4-(4-(p-Bromophenyl)-4-hydroxypiperidinol)-4'-fluorobutyrophenone
  • 5-21-02-00382 (Beilstein Handbook Reference)
  • BRN 1552256
  • Bromperidol
  • Bromperidolum
  • Bromperidolum [INN-Latin]
  • CC 2489
  • EINECS 233-943-3
  • Impromen
  • R 11,333
  • R 11333
  • UNII-LYH6F7I22E

Systematic Names

  • 1-Butanone, 4-(4-(4-bromophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-
  • 4-(4-(4-Bromophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
  • Bromperidol
  • Butyrophenone, 4-(4-(p-bromophenyl)-4-hydroxypiperidino)-4'-fluoro-

Registry Numbers

CAS Registry Number

  • 10457-90-6

FDA UNII

  • LYH6F7I22E

System Generated Number

  • 0010457906

Structure Descriptors

InChI

1S/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChIKey

RKLNONIVDFXQRX-UHFFFAOYSA-N

Smiles

c1cc(ccc1C(=O)CCCN2CCC(CC2)(c3ccc(cc3)Br)O)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 156mg/kg (156mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
mouse LD50 intravenous 18900ug/kg (18.9mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974.
mouse LD50 oral 174mg/kg (174mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
mouse LD50 subcutaneous 114mg/kg (114mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974.
rat LD50 intraperitoneal 323mg/kg (323mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
rat LD50 intravenous 10mg/kg (10mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
rat LD50 oral 359mg/kg (359mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974.
rat LD50 subcutaneous 84mg/kg (84mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 155 deg C   EXP
pKa Dissociation Constant 8.65 (none)   EXP
log P (octanol-water) 4.450 (none)   EST
Water Solubility 90 mg/L   EXP
Atmospheric OH Rate Constant 1.16E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.