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Substance Name: R 56865
RN: 104606-13-5
UNII: 8MUQ2U7UV6
InChIKey: PZPXREFPAFDHNG-UHFFFAOYSA-N

Note

  • Prevents electrical & mechanical signs of ouabain intoxication in guinea pig papillary muscle.

Molecular Formula

  • C23-H28-F-N3-O-S

Molecular Weight

  • 413.558
 

Classification Codes

  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
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Names and Synonyms

Name of Substance

  • R 56865

Synonyms

  • BRN 6616961
  • N-(1-(4-(4-Fluorophenoxy)butyl)-4-piperidinyl)-N-methyl-2-benzothiazolamine
  • R 56865
  • UNII-8MUQ2U7UV6

Systematic Name

  • 2-Benzothiazolamine, N-(1-(4-(4-fluorophenoxy)butyl)-4-piperidinyl)-N-methyl-

Registry Numbers

CAS Registry Number

  • 104606-13-5

FDA UNII

  • 8MUQ2U7UV6

System Generated Number

  • 0104606135

Structure Descriptors

InChI

1S/C23H28FN3OS/c1-26(23-25-21-6-2-3-7-22(21)29-23)19-12-15-27(16-13-19)14-4-5-17-28-20-10-8-18(24)9-11-20/h2-3,6-11,19H,4-5,12-17H2,1H3

InChIKey

PZPXREFPAFDHNG-UHFFFAOYSA-N

Smiles

c1(OCCCCN2CCC(N(c3sc4ccccc4n3)C)CC2)ccc(cc1)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 14100ug/kg (14.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cardiovascular Drug Reviews. Vol. 8, Pg. 238, 1990.
mouse LD50 intravenous 13600ug/kg (13.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cardiovascular Drug Reviews. Vol. 8, Pg. 238, 1990.
mouse LD50 oral 35mg/kg (35mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cardiovascular Drug Reviews. Vol. 8, Pg. 238, 1990.
rat LD50 oral 154mg/kg (154mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cardiovascular Drug Reviews. Vol. 8, Pg. 238, 1990.