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Substance Name: Afuresertib [USAN:INN]
RN: 1047644-62-1
UNII: 8739X25QI3
InChIKey: AFJRDFWMXUECEW-LBPRGKRZSA-N

Notes

  • An AKT inhibitor.
  • NCI: An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Formula

  • C18-H17-Cl2-F-N4-O-S

Molecular Weight

  • 427.3293
 
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Names and Synonyms

Name of Substance

  • Afuresertib [USAN:INN]

Synonyms

  • Afuresertib
  • GSK 2110183C
  • GSK2110183C
  • UNII-8739X25QI3

Systematic Names

  • 2-Thiophenecarboxamide, N-((1S)-2-amino-1-((3-fluorophenyl)methyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-
  • N-((1S)-1-(aminomethyl)-2-(3-fluorophenyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide

Registry Numbers

CAS Registry Number

  • 1047644-62-1

FDA UNII

  • 8739X25QI3

Other Registry Number

  • 1343402-83-4

System Generated Number

  • 1047644621

Structure Descriptors

InChI

1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)/t12-/m0/s1

InChIKey

AFJRDFWMXUECEW-LBPRGKRZSA-N

Smiles

Cn1c(c(cn1)Cl)c2cc(sc2Cl)C(=O)N[C@@H](Cc3cccc(c3)F)CN