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Substance Name: Tofenacin hydrochloride [USAN]
RN: 10488-36-5
UNII: 3A10ND4DWR
InChIKey: YAXWIYFUVISXRS-UHFFFAOYSA-N

Classification Codes

  • Anticholinergic
  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H21-N-O.Cl-H

Molecular Weight

  • 291.82
 
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Names and Synonyms

Name of Substance

  • Tofenacin hydrochloride
  • Tofenacin hydrochloride [USAN]

Synonyms

  • (2-(Phenyl-o-tolylmethoxy)ethyl)methylamine hydrochloride
  • BS 7331
  • BS 7331 hydrochloride
  • EINECS 234-011-9
  • Ethanamine, N-methyl-2-((2-methylphenyl)phenylmethoxy)-, hydrochloride
  • N-Demethylorphenadrine hydrochloride
  • N-Methyl-2-((o-methyl-alpha-phenylbenzyl)oxy)ethylamine hydrochloride
  • N-Methyl-2-(alpha-(2-tolylbenzyl)oxy)ethylamine hydrochloride
  • N-Methylaminoethyl 2-methylbenzhydryl ether hydrochloride
  • NSC 113809
  • NSC 169432
  • Phenyl-(o-tolylmethyl) methylaminoethyl ether hydrochloride
  • Tofacine
  • Tofenacin HCl
  • Tofenacin hydrochloride
  • Tofenacine
  • Tofenacine hydrochloride
  • UNII-3A10ND4DWR

Systematic Names

  • Ethanamine, N-methyl-2-((2-methylphenyl)phenylmethoxy)-, hydrochloride
  • Ethylamine, N-methyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, hydrochloride
  • Tofenacin hydrochloride

Registry Numbers

CAS Registry Number

  • 10488-36-5

FDA UNII

  • 3A10ND4DWR

Related Registry Number

  • 15301-93-6 (Parent)

System Generated Number

  • 0010488365

Molecular Formulas

Molecular Formula

  • C17-H21-N-O.Cl-H

Molecular Formula Fragments

  • C17-H21-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H

InChIKey

YAXWIYFUVISXRS-UHFFFAOYSA-N

Smiles

c1([C@@H](c2ccccc2)OCC[NH2+]C)c(cccc1)C.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 90mg/kg (90mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 375, 1972.
guinea pig LD50 subcutaneous 92mg/kg (92mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 28, 1969.
mouse LD50 intraperitoneal 55mg/kg (55mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 28, 1969.
mouse LD50 intravenous 32mg/kg (32mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 375, 1972.
mouse LD50 oral 182mg/kg (182mg/kg) BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 28, 1969.
mouse LD50 subcutaneous 82mg/kg (82mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 28, 1969.
rat LD50 intraperitoneal 72mg/kg (72mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 28, 1969.
rat LD50 intravenous 15mg/kg (15mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 375, 1972.
rat LD50 oral 400mg/kg (400mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 375, 1972.