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Substance Name: Arbekacin sulfate [JAN]
RN: 104931-87-5
UNII: G7395HZ992
InChIKey: UTUVRPOLEMRKQC-XDJMXTNXSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C22-H44-N6-O10.x-H2-O4-S

Molecular Weight

  • 650.699
 
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Names and Synonyms

Name of Substance

  • Arbekacin sulfate [JAN]
  • Habekacin

Synonyms

  • Arbekacin sulfate
  • Habekacin
  • NPC-14
  • UNII-G7395HZ992

Systematic Name

  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl-(1-4))-N'-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, sulfate (salt)

Registry Numbers

CAS Registry Number

  • 104931-87-5

FDA UNII

  • G7395HZ992

System Generated Number

  • 0104931875

Molecular Formulas

Molecular Formula

  • C22-H44-N6-O10.x-H2-O4-S

Molecular Formula Fragments

  • C22-H44-N6-O10
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C22H44N6O10.H2O4S/c23-4-3-12(30)20(34)28-11-5-10(26)18(37-21-9(25)2-1-8(6-24)35-21)17(33)19(11)38-22-16(32)14(27)15(31)13(7-29)36-22;1-5(2,3)4/h8-19,21-22,29-33H,1-7,23-27H2,(H,28,34);(H2,1,2,3,4)/t8-,9+,10-,11+,12-,13+,14-,15+,16+,17-,18+,19-,21+,22+;/m0./s1

InChIKey

UTUVRPOLEMRKQC-XDJMXTNXSA-N

Smiles

O1[C@H](O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]2[C@H](N)CC[C@H](CN)O2)N)NC([C@H](CCN)O)=O)[C@H](O)[C@@H](N)[C@@H](O)[C@H]1CO.S(O)(O)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intramuscular 400mg/kg (400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7587, 1986.
dog LDLo intravenous 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7587, 1986.
mouse LD50 intramuscular 372mg/kg (372mg/kg) BEHAVIORAL: AGGRESSION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7473, 1986.
mouse LD50 intraperitoneal 540mg/kg (540mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: AGGRESSION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7473, 1986.
mouse LD50 intravenous 82300ug/kg (82.3mg/kg) BEHAVIORAL: AGGRESSION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7473, 1986.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7473, 1986.
mouse LD50 subcutaneous 476mg/kg (476mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: AGGRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7473, 1986.
rat LD50 intramuscular 621mg/kg (621mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: AGGRESSION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7473, 1986.
rat LD50 intraperitoneal 588mg/kg (588mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 41, Pg. 2221, 1999.
rat LD50 intravenous 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: AGGRESSION
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7473, 1986.
rat LD50 oral > 5gm/kg (5000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 7473, 1986.