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Substance Name: Caprolactam
RN: 105-60-2
UNII: 6879X594Z8
InChIKey: JBKVHLHDHHXQEQ-UHFFFAOYSA-N

Note

  • Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. Can cause local irritation.

Molecular Formula

  • C6-H11-N-O

Molecular Weight

  • 113.1589
 

Classification Codes

Classification Codes

  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 4
  • Reportable Quantity (RQ) = 5000 lb
  • TWA 5 ppm inhalable fraction, vapor and aerosol; Not suspected as a human carcinogen

Names and Synonyms

Name of Substance

  • Caprolactam

MeSH Heading

  • Caprolactam

Synonyms

  • 1,6-Hexalactam
  • 1,6-Hexolactam
  • 1-Aza-2-cycloheptanone
  • 2-Azacycloheptanone
  • 2-Ketohexamethylenimine
  • 2-Oxohexamethyleneimine
  • 2-Oxohexamethylenimine
  • 2-Perhydroazepinone
  • 2H-Azepin-2-one, hexahydro-
  • 2H-Azepin-7-one, hexahydro-
  • 5-21-06-00444 (Beilstein Handbook Reference)
  • 6-Aminocaproic acid lactam
  • 6-Aminohexanoic acid cyclic lactam
  • 6-Caprolactam
  • 6-Hexanelactam
  • A1030
  • AI3-14515
  • Aminocaproic lactam
  • BRN 0106934
  • Caprolactam
  • Caprolactam monomer
  • Caprolattame
  • Caprolattame [French]
  • Capron PK4
  • CCRIS 119
  • Cyclohexanone iso-oxime
  • e-Kaprolaktam
  • e-Kaprolaktam [Czech]
  • EC 203-313-2
  • EINECS 203-313-2
  • epsilon-Caprolactam
  • Epsylon kaprolaktam
  • Epsylon kaprolaktam [Polish]
  • Extrom 6N
  • Hexahydro-2-azepinone
  • Hexahydro-2H-azepin-2-one
  • Hexamethylenimine, 2-oxo-
  • Hexanoic acid, 6-amino-, cyclic lactam
  • Hexanoic acid, 6-amino-, lactam
  • Hexanolactam
  • Hexanone isoxime
  • Hexanonisoxim
  • Hexanonisoxim [German]
  • HSDB 187
  • Kapromine
  • NCI-C50646
  • NSC 117393
  • Stilon
  • UNII-6879X594Z8

Systematic Names

  • 2H-Azepin-2-one, hexahydro-
  • epsilon-Caprolactam
  • Hexahydro-2H-azepin-2-one (9CI)

Superlist Names

  • 2H-Azepin-2-one, hexahydro-
  • Caprolactam
  • Caprolactam dust and vapor
  • Caprolactam solution

Registry Numbers

CAS Registry Number

  • 105-60-2

FDA UNII

  • 6879X594Z8

Other Registry Numbers

  • 117955-36-9
  • 168214-28-6
  • 2953-03-9
  • 32838-21-4
  • 32838-23-6
  • 34876-18-1

System Generated Number

  • 0000105602

Structure Descriptors

InChI

1S/C6H11NO/c8-6-4-2-1-3-5-7-6/h1-5H2,(H,7,8)

InChIKey

JBKVHLHDHHXQEQ-UHFFFAOYSA-N

Smiles

C1(CCCCCN1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo subcutaneous 2800mg/kg (2800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
guinea pig LDLo subcutaneous 950mg/kg (950mg/kg)   Medicina del Lavoro. Industrial Medicine. Vol. 43, Pg. 124, 1952.
human TCLo inhalation 100ppm (100ppm) LUNGS, THORAX, OR RESPIRATION: COUGH American Industrial Hygiene Association Journal. Vol. 34, Pg. 384, 1973.
mouse LC50 inhalation 450mg/m3 (450mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 10(10), Pg. 54, 1966.
mouse LD50 intraperitoneal 650mg/kg (650mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANALGESIA
Journal of Pharmaceutical Sciences. Vol. 60, Pg. 1058, 1971.
mouse LD50 intravenous 480mg/kg (480mg/kg)   IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 39, Pg. 247, 1986.
mouse LD50 oral 930mg/kg (930mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 10(10), Pg. 54, 1966.
mouse LD50 subcutaneous 750mg/kg (750mg/kg)   IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 39, Pg. 247, 1986.
mouse LD50 unreported 930mg/kg (930mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 33, 1990.
rabbit LD intravenous > 300mg/kg (300mg/kg)   British Journal of Industrial Medicine. Vol. 11, Pg. 1, 1954.
rabbit LD intravenous > 300mg/kg (300mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Industrial Medicine. Vol. 11, Pg. 1, 1954.
rabbit LD50 skin 1410uL/kg (1.41mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rabbit LD50 unreported 1gm/kg (1000mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 33, 1990.
rat LC50 inhalation 300mg/m3/2H (300mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 32, 1982.
rat LD50 oral 1210mg/kg (1210mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
National Toxicology Program Technical Report Series. Vol. NTP-TR-214, Pg. 1982,
rat LD50 skin > 2gm/kg (2000mg/kg)   National Technical Information Service. Vol. OTS0557720,
rat LD50 unreported 580mg/kg (580mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 33, 1990.
rat LDLo intraperitoneal 800mg/kg (800mg/kg)   British Journal of Industrial Medicine. Vol. 11, Pg. 1, 1954.
rat LDLo intraperitoneal 800mg/kg (800mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Industrial Medicine. Vol. 11, Pg. 1, 1954.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 69.3 deg C   EXP
Boiling Point 270 deg C   EXP
log P (octanol-water) 0.660 (none)   EST
Water Solubility 7.72E+05 mg/L 10 EXP
Henry's Law Constant 2.53E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.84E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.