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Substance Name: Caprolactam
RN: 105-60-2
UNII: 6879X594Z8
InChIKey: JBKVHLHDHHXQEQ-UHFFFAOYSA-N

Note

  • Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. Can cause local irritation.

Molecular Formula

  • C6-H11-N-O

Molecular Weight

  • 113.1589
 

Classification Codes

Classification Codes

  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 4
  • Reportable Quantity (RQ) = 5000 lb
  • TWA 5 ppm inhalable fraction, vapor and aerosol; Not suspected as a human carcinogen

Names and Synonyms

Name of Substance

  • Caprolactam

MeSH Heading

  • Caprolactam

Synonyms

  • 1,6-Hexalactam
  • 1,6-Hexolactam
  • 1-Aza-2-cycloheptanone
  • 2-Azacycloheptanone
  • 2-Ketohexamethylenimine
  • 2-Oxohexamethyleneimine
  • 2-Oxohexamethylenimine
  • 2-Perhydroazepinone
  • 2H-Azepin-2-one, hexahydro-
  • 2H-Azepin-7-one, hexahydro-
  • 5-21-06-00444 (Beilstein Handbook Reference)
  • 6-Aminocaproic acid lactam
  • 6-Aminohexanoic acid cyclic lactam
  • 6-Caprolactam
  • 6-Hexanelactam
  • A1030
  • AI3-14515
  • Aminocaproic lactam
  • BRN 0106934
  • Caprolactam
  • Caprolactam monomer
  • Caprolattame
  • Caprolattame [French]
  • Capron PK4
  • CCRIS 119
  • Cyclohexanone iso-oxime
  • e-Kaprolaktam
  • e-Kaprolaktam [Czech]
  • EC 203-313-2
  • EINECS 203-313-2
  • epsilon-Caprolactam
  • Epsylon kaprolaktam
  • Epsylon kaprolaktam [Polish]
  • Extrom 6N
  • Hexahydro-2-azepinone
  • Hexahydro-2H-azepin-2-one
  • Hexamethylenimine, 2-oxo-
  • Hexanoic acid, 6-amino-, cyclic lactam
  • Hexanoic acid, 6-amino-, lactam
  • Hexanolactam
  • Hexanone isoxime
  • Hexanonisoxim
  • Hexanonisoxim [German]
  • HSDB 187
  • Kapromine
  • NCI-C50646
  • NSC 117393
  • Stilon
  • UNII-6879X594Z8

Systematic Names

  • 2H-Azepin-2-one, hexahydro-
  • epsilon-Caprolactam
  • Hexahydro-2H-azepin-2-one (9CI)

Superlist Names

  • 2H-Azepin-2-one, hexahydro-
  • Caprolactam
  • Caprolactam dust and vapor
  • Caprolactam solution

Registry Numbers

CAS Registry Number

  • 105-60-2

FDA UNII

  • 6879X594Z8

Other Registry Numbers

  • 117955-36-9
  • 168214-28-6
  • 2953-03-9
  • 32838-21-4
  • 32838-23-6
  • 34876-18-1

System Generated Number

  • 0000105602

Structure Descriptors

InChI

1S/C6H11NO/c8-6-4-2-1-3-5-7-6/h1-5H2,(H,7,8)

InChIKey

JBKVHLHDHHXQEQ-UHFFFAOYSA-N

Smiles

C1(CCCCCN1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo subcutaneous 2800mg/kg (2800mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
guinea pig LDLo subcutaneous 950mg/kg (950mg/kg)   Medicina del Lavoro. Industrial Medicine. Vol. 43, Pg. 124, 1952.
human TCLo inhalation 100ppm (100ppm) LUNGS, THORAX, OR RESPIRATION: COUGH American Industrial Hygiene Association Journal. Vol. 34, Pg. 384, 1973.
mouse LC50 inhalation 450mg/m3 (450mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 10(10), Pg. 54, 1966.
mouse LD50 intraperitoneal 650mg/kg (650mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANALGESIA

BEHAVIORAL: ANTIPSYCHOTIC
Journal of Pharmaceutical Sciences. Vol. 60, Pg. 1058, 1971.
mouse LD50 intravenous 480mg/kg (480mg/kg)   IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 39, Pg. 247, 1986.
mouse LD50 oral 930mg/kg (930mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 10(10), Pg. 54, 1966.
mouse LD50 subcutaneous 750mg/kg (750mg/kg)   IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 39, Pg. 247, 1986.
mouse LD50 unreported 930mg/kg (930mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 33, 1990.
rabbit LD intravenous > 300mg/kg (300mg/kg)   British Journal of Industrial Medicine. Vol. 11, Pg. 1, 1954.
rabbit LD intravenous > 300mg/kg (300mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Industrial Medicine. Vol. 11, Pg. 1, 1954.
rabbit LD50 skin 1410uL/kg (1.41mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rabbit LD50 unreported 1gm/kg (1000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 33, 1990.
rat LC50 inhalation 300mg/m3/2H (300mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 32, 1982.
rat LD50 oral 1210mg/kg (1210mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-214, Pg. 1982,
rat LD50 oral 1210mg/kg (1210mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Toxicology Program Technical Report Series. Vol. NTP-TR-214, Pg. 1982,
rat LD50 skin > 2gm/kg (2000mg/kg)   National Technical Information Service. Vol. OTS0557720,
rat LD50 unreported 580mg/kg (580mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 33, 1990.
rat LDLo intraperitoneal 800mg/kg (800mg/kg)   British Journal of Industrial Medicine. Vol. 11, Pg. 1, 1954.
rat LDLo intraperitoneal 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
British Journal of Industrial Medicine. Vol. 11, Pg. 1, 1954.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 69.3 deg C   EXP
Boiling Point 270 deg C   EXP
log P (octanol-water) 0.660 (none)   EST
Water Solubility 7.72E+05 mg/L 10 EXP
Henry's Law Constant 2.53E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.84E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.