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Substance Name: Mometasone [INN:BAN]
RN: 105102-22-5
UNII: 8HR4QJ6DW8
InChIKey: QLIIKPVHVRXHRI-CXSFZGCWSA-N

Note

  • NCI: Mometasone furoate. The furoate salt form of mometasone, a synthetic topical glucocorticosteroid receptor agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Mometasone furoate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone furoate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2. (NCI Thesaurus)

Molecular Formula

  • C22-H28-Cl2-O4

Molecular Weight

  • 427.3652
 

Classification Codes

  • Anti-Allergic Agents
  • Anti-Inflammatory Agents

Names and Synonyms

Name of Substance

  • Mometasone [INN:BAN]

Synonyms

  • (+)-Mometasone
  • Mometasona
  • Mometasona [Spanish]
  • Mometasone
  • Mometasone, inhaled
  • Mometasonum
  • Mometasonum [Latin]
  • UNII-8HR4QJ6DW8

Systematic Name

  • Pregna-1,4-diene-3,20-dione, 9,21-dichloro-11,17-dihydroxy-16-methyl-, (11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 105102-22-5

FDA UNII

  • 8HR4QJ6DW8

System Generated Number

  • 0105102225

Structure Descriptors

InChI

1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChIKey

QLIIKPVHVRXHRI-CXSFZGCWSA-N

Smiles

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)Cl)C