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Substance Name: Prophenoxamine
RN: 10535-87-2
UNII: 0LZR2SJI39
InChIKey: AKYFHMMTXWERNE-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H31-N-O.Cl-H

Molecular Weight

  • 361.954
 
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Names and Synonyms

Results Name

  • Prophenoxamine

Name of Substance

  • Prophenoxamine hydrochloride

Synonyms

  • 1-(p-Ethoxyphenyl)-1-diethylamino-3-methyl-3-phenylpropane hydrochloride
  • EINECS 234-108-6
  • Phenyl-2-amino-1-propane hydrochloride
  • Prophenoxamine
  • SP 725
  • UNII-0LZR2SJI39

Systematic Names

  • (1-(4-Ethoxyphenyl)butyl)diethylammonium chloride
  • Benzenepropanamine, alpha-(4-ethoxyphenyl)-N,N-diethyl-gamma-methyl-, hydrochloride (9CI)
  • Benzylamine, p-ethoxy-N,N-diethyl-alpha-(beta-methylphenethyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 10535-87-2

FDA UNII

  • 0LZR2SJI39

System Generated Number

  • 0010535872

Molecular Formulas

Molecular Formula

  • C22-H31-N-O.Cl-H

Molecular Formula Fragments

  • C22-H31-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H31NO.ClH/c1-5-23(6-2)22(17-18(4)19-11-9-8-10-12-19)20-13-15-21(16-14-20)24-7-3;/h8-16,18,22H,5-7,17H2,1-4H3;1H

InChIKey

AKYFHMMTXWERNE-UHFFFAOYSA-N

Smiles

c1([C@@H]([NH+](CC)CC)C[C@@H](c2ccccc2)C)ccc(OCC)cc1.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 90mg/kg (90mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 178, 1962.
mouse LD50 oral 270mg/kg (270mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 12, Pg. 459, 1977.
mouse LD50 subcutaneous 643mg/kg (643mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 178, 1962.
rat LD50 intraperitoneal 185mg/kg (185mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 178, 1962.
rat LD50 oral 1887mg/kg (1887mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 178, 1962.
rat LD50 subcutaneous 2358mg/kg (2358mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 178, 1962.