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Substance Name: Tamoxifen [INN:BAN]
RN: 10540-29-1
UNII: 094ZI81Y45
InChIKey: NKANXQFJJICGDU-QPLCGJKRSA-N
Note
- One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Molecular Formula
- C26-H29-N-O
Molecular Weight
- 371.521
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Antiviral (COVID-19)
- Bone Density Conservation Agents
- Drug / Therapeutic Agent
- Estrogen Antagonists
- Estrogen Receptor Modulators
- Hormone Antagonists
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Human Data
- Mutation Data
- Reproductive Effect
- Selective Estrogen Receptor Modulators
- Tumor Data
Superlist Classification Codes
- Known to be a Human Carcinogen
- Overall Carcinogenic Evaluation: Group 1
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Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Tamoxifen [INN:BAN]
MeSH Heading
- Tamoxifen
Synonyms
- (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
- (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
- 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
- 1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
- CCRIS 3275
- Citofen
- Crisafeno
- Diemon
- EC 234-118-0
- EINECS 234-118-0
- HSDB 6782
- ICI 47699
- Istubol
- Nolvadex
- NSC 180973
- Oncomox
- Retaxim
- Soltamox
- Tamizam
- Tamoxen
- Tamoxifen
- Tamoxifen (Z)
- Tamoxifene
- Tamoxifene [INN-French]
- Tamoxifeno
- Tamoxifeno [INN-Spanish]
- Tamoxifenum
- Tamoxifenum [INN-Latin]
- trans-Tamoxifen
- UNII-094ZI81Y45
- Valodex
Systematic Names
- Ethanamine, 2-(4-((1Z)-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-
- Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-
- Ethylamine, N,N-dimethyl-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-, (Z)-
- Tamoxifen
Superlist Names
- Tamoxifen
- Tamoxifen and its salts
Registry Numbers
CAS Registry Number
- 10540-29-1
FDA UNII
- 094ZI81Y45
Related Registry Number
- 54965-24-1 (citrate)
System Generated Number
- 0010540291
Structure Descriptors
InChI
InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-InChIKey
NKANXQFJJICGDU-QPLCGJKRSA-NSmiles
CC\C(=C(/c1ccccc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 575mg/kg (575mg/kg) | Journal of Antibiotics. Vol. 43, Pg. 1533, 1990. | |
mouse | LD50 | oral | 2150mg/kg (2150mg/kg) | Drugs of the Future. Vol. 9, Pg. 186, 1984. | |
rat | LD50 | intraperitoneal | 700mg/kg (700mg/kg) | Drugs of the Future. Vol. 9, Pg. 186, 1984. | |
rat | LD50 | oral | 4100mg/kg (4100mg/kg) | Drugs of the Future. Vol. 9, Pg. 186, 1984. | |
women | TDLo | oral | 5600ug/kg/1W- (5.6mg/kg) | SKIN AND APPENDAGES (SKIN): BREAST: OTHER | British Medical Journal. Vol. 291, Pg. 1172, 1985. |
women | TDLo | unreported | 200ug/kg/D (0.2mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA | Cancer Treatment Reports. Vol. 60, Pg. 1431, 1976. |
women | TDLo | unreported | 5600ug/kg/2W- (5.6mg/kg) | MUSCULOSKELETAL: JOINTS BLOOD: NORMOCYTIC ANEMIA | British Journal of Rheumatology. Vol. 33, Pg. 583, 1994. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 97 | deg C | EXP | |
log P (octanol-water) | 6.300 | (none) | EST | |
Atmospheric OH Rate Constant | 2.41E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.