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Substance Name: Fasudil hydrochloride
RN: 105628-07-7
UNII: SQ04N8S7BR
InChIKey: LFVPBERIVUNMGV-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C14-H17-N3-O2-S.Cl-H

Molecular Weight

  • 327.8342
 
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Names and Synonyms

Name of Substance

  • Fasudil hydrochloride

Synonyms

  • AT 877 hydrochloride
  • Fasudil HCl
  • Fasudil hydrochloride
  • HA 1077 hydrochloride
  • Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride
  • UNII-SQ04N8S7BR

Systematic Name

  • 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 105628-07-7

FDA UNII

  • SQ04N8S7BR

Other Registry Number

  • 133337-43-6

System Generated Number

  • 0105628077

Molecular Formulas

Molecular Formula

  • C14-H17-N3-O2-S.Cl-H

Molecular Formula Fragments

  • C14-H17-N3-O2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

InChIKey

LFVPBERIVUNMGV-UHFFFAOYSA-N

Smiles

Cl.O=S(=O)(N1CCCNCC1)c2cccc3cnccc23

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous 20mg/kg (20mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
mouse LD50 intravenous 67600ug/kg (67.6mg/kg) BEHAVIORAL: STRAUB TAIL

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 oral 274mg/kg (274mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 subcutaneous 124mg/kg (124mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 intravenous 59900ug/kg (59.9mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 oral 335mg/kg (335mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 subcutaneous 123mg/kg (123mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,