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Substance Name: Alteplase [USAN:USP:INN:BAN:JAN]
RN: 105857-23-6
UNII: 1RXS4UE564

Molecular Formula

  • C2569-H3894-N746-O781-S40
 

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
  • Plasminogen Activator
  • Plasminogen Activators

Names and Synonyms

Name of Substance

  • Alteplase [USAN:USP:INN:BAN:JAN]

Synonyms

  • A serine protease with a primary sequence composed of 527 amino acids. The sequence is identical to the naturally occurring protease produced by endothelial cells of vessel walls. Plasminogen activator (human tissue-type protein moiety)
  • Actilyse
  • Activase
  • Alteplase
  • Alteplasi
  • Alteplasum
  • Alteplasum [INN-Latin]
  • Cathflo Activase
  • GRTPA
  • Recombinant human tissue-type plasminogen activator
  • rt-PA
  • rtPA
  • SRT-PA
  • Tissue plasminogen activator (recombinant human)
  • UNII-1RXS4UE564

Systematic Name

  • Plasminogen activator (human tissue-type 2-chain form protein moiety)

Registry Numbers

CAS Registry Number

  • 105857-23-6

FDA UNII

  • 1RXS4UE564

Other Registry Number

  • 93928-26-8

System Generated Number

  • 0105857236

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous 5800ku/kg (5800000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
mouse LD50 intravenous 30040ku/kg (30040000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
mouse LD50 oral > 58000ku/kg (58000000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
rat LD50 intravenous 17630ku/kg (17630000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
rat LD50 oral 34800ku/kg (34800000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.