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Substance Name: Pexastimogene devacirepvec
RN: 1058624-46-6
UNII: K82DG47I0G

Note

  • NCI: A thymidine kinase-deleted vaccinia virus expressing human GM-CSF (hGM-CSF) with oncolytic activity. Upon intratumoral or intravenous administration, thymidine kinase-deleted vaccinia-hGM-CSF JX-594 may selectively infect and lyse tumor cells. While vaccinia displays a natural tumor cell tropism, deletion of the thymidine kinase gene increases the tumor selectivity of vaccinia by limiting viral replication to transformed cells. hGM-CSF expression by this agent may help recruit antigen processing cells (APCs), such as denritic cells and macrophages, to virally infected tumor cells, initiating a systemic antitumoral immune response. (NCI Thesaurus)

Molecular Formula

  • Unspecified
 
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Names and Synonyms

Name of Substance

  • Pexastimogene devacirepvec

Synonyms

  • JX-594
  • JX594
  • Thymidine kinase-deleted vaccinia-hGM-CSF
  • UNII-K82DG47I0G

Systematic Name

  • JX 594

Registry Numbers

CAS Registry Number

  • 1058624-46-6

FDA UNII

  • K82DG47I0G

Other Registry Number

  • 1138339-63-5

System Generated Number

  • 1058624466