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Substance Name: Pyrroxamycin
RN: 105888-54-8
UNII: V9AXN5H81T
InChIKey: CUPRKSFMHRXAFA-NSHDSACASA-N

Note

  • Isolated from Streptomyces sp. S46506.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C12-H6-Cl4-N2-O4

Molecular Weight

  • 384.001
 
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Names and Synonyms

Name of Substance

  • Pyrroxamycin

Synonyms

  • (-)-2,3-Dichloro-5-(6,8-dichloro-4H-1,3-benzodioxin-4-yl)-4-nitro-1H-pyrrole
  • 4,5-Dichloro-2-(6',8'-dichloro-4'-H-1,3-benzodioxin-4'-yl)-3-nitropyrrole
  • AL-R2081
  • Dioxapyrrolomycin
  • LL-F42248-alpha
  • Pyrroxamycin
  • UNII-V9AXN5H81T

Systematic Name

  • 1H-Pyrrole, 2,3-dichloro-5-(6,8-dichloro-4H-1,3-benzodioxin-4-yl)-4-nitro-, (-)-

Registry Numbers

CAS Registry Number

  • 105888-54-8

FDA UNII

  • V9AXN5H81T

System Generated Number

  • 0105888548

Structure Descriptors

InChI

1S/C12H6Cl4N2O4/c13-4-1-5-10(6(14)2-4)21-3-22-11(5)8-9(18(19)20)7(15)12(16)17-8/h1-2,11,17H,3H2/t11-/m0/s1

InChIKey

CUPRKSFMHRXAFA-NSHDSACASA-N

Smiles

[nH]1c(c(c(c1[C@H]1OCOc2c1cc(cc2Cl)Cl)[N+](=O)[O-])Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 125mg/kg (125mg/kg)   Journal of Antibiotics. Vol. 40, Pg. 899, 1987.
mouse LD50 oral 13mg/kg (13mg/kg)   Journal of Antibiotics. Vol. 40, Pg. 233, 1987.