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Substance Name: delta(2-89)-Tissue plasminogen activator
RN: 105913-11-9

Note

  • Deletion mutant of t-PA which lacks the finger & epidermal growth factor domains; fibrin interaction of this molecule mediated by the kringle region.
 

Classification Code

  • Reproductive Effect
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Links to Resources

Names and Synonyms

Name of Substance

  • delta(2-89)-Tissue plasminogen activator

Synonyms

  • AK-124
  • Angiokinase
  • CCRIS 3520
  • GMK 527
  • Recombinant tissue-type plasminogen activator
  • rt-PA
  • Tisokinase

Systematic Names

  • Plasminogen activator
  • Plasminogen activator ak-124

Registry Numbers

CAS Registry Number

  • 105913-11-9

System Generated Number

  • 0105913119

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous > 3300ku/kg (3300000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 33, Pg. 998, 1991.
mouse LD50 intravenous 51800ug/kg (51.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
mouse LD50 subcutaneous > 100mg/kg (100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
rat LD50 intravenous 30400ug/kg (30.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
rat LD50 subcutaneous > 60mg/kg (60mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,