|
|
Substance Name: Doxycycline Hydrochloride [JAN]
RN: 10592-13-9
UNII: 4182Z6T2ET
InChIKey: RUYHIJHUVHIMIR-CVHRZJFOSA-N
Note
- A synthetic TETRACYCLINE derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (MALARIA, FALCIPARUM).
Molecular Formula
- C22-H24-N2-O8.Cl-H
Molecular Weight
- 480.8985
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Drug / Therapeutic Agent
- Reproductive Effect
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Doxycycline Hydrochloride [JAN]
Synonyms
- 6-Desoxy-5-hydroxytetracycline hydrochloride
- alpha-6-Deoxy-5-hydroxytetracycline hydrochloride
- Biocamycin
- Deoxy-5-hydroxytetracycline hydrochloride
- Deoxyoxytetracycline hydrochloride
- Doxigalumicina
- Doxy-II
- Doxy-tablinen
- Doxycycline hydrochloride
- Doxylin
- Ecodox
- EINECS 234-198-7
- Hydramycin
- Idocyklin
- Liomycin
- Mespafin
- Midoxin
- Nivocilin
- Novadox
- NSC 756751
- Retens
- Roximycin
- Samecin
- Tanamicin
- Tecacin
- Tetradox
- UNII-4182Z6T2ET
- Vibra-tabs
- Vibradox
- Vibramycin hyclate
- Vibramycin hydrochloride
Systematic Names
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6R,12aS)-
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-
- 2-Naphthacenecarboxamide, 4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride
Registry Numbers
CAS Registry Number
- 10592-13-9
FDA UNII
- 4182Z6T2ET
Other Registry Numbers
- 100929-47-3
- 53108-42-2
- 61281-03-6
System Generated Number
- 0010592139
Molecular Formulas
Molecular Formula
- C22-H24-N2-O8.Cl-H
Molecular Formula Fragments
- C22-H24-N2-O8
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H/t7-,10+,14+,15-,17-,22-;/m0./s1InChIKey
RUYHIJHUVHIMIR-CVHRZJFOSA-NSmiles
Cl.C[C@@H]1[C@H]2[C@H](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | > 100mg/kg (100mg/kg) | Drugs in Japan Vol. -, Pg. 840, 1995. | |
dog | LD50 | oral | > 500mg/kg (500mg/kg) | Drugs in Japan Vol. -, Pg. 714, 1990. | |
mouse | LD50 | intraperitoneal | 179mg/kg (179mg/kg) | Drugs in Japan Vol. -, Pg. 714, 1990. | |
mouse | LD50 | intravenous | 201mg/kg (201mg/kg) | Drugs in Japan Vol. -, Pg. 840, 1995. | |
mouse | LD50 | oral | 1890mg/kg (1890mg/kg) | Drugs in Japan Vol. 6, Pg. 505, 1982. | |
mouse | LD50 | subcutaneous | 700mg/kg (700mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 1447, 1980. | |
rat | LD50 | intraperitoneal | 714mg/kg (714mg/kg) | Drugs in Japan Vol. -, Pg. 840, 1995. | |
rat | LD50 | intravenous | 137mg/kg (137mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 1447, 1980. |
rat | LD50 | oral | 1700mg/kg (1700mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: MUSCLE WEAKNESS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 1447, 1980. |
rat | LD50 | subcutaneous | 700mg/kg (700mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 1447, 1980. |