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Substance Name: Clodronic acid [USAN:INN:BAN]
RN: 10596-23-3
UNII: 0813BZ6866
InChIKey: ACSIXWWBWUQEHA-UHFFFAOYSA-N

Note

  • A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

Molecular Formula

  • C-H4-Cl2-O6-P2

Molecular Weight

  • 244.8906
 

Classification Codes

  • Bone Density Conservation Agents
  • Drug / Therapeutic Agent
  • Regulator (Calcium)

Names and Synonyms

Name of Substance

  • Clodronic acid
  • Clodronic acid [USAN:INN:BAN]

MeSH Heading

  • Clodronic acid

Synonyms

  • (Dichloromethylene)bisphosphonic acid
  • (Dichloromethylene)diphosphonic acid
  • Acide clodronique
  • Acide clodronique [INN-French]
  • Acido clodronico
  • Acido clodronico [INN-Spanish]
  • Acidum clodronicum
  • Acidum clodronicum [INN-Latin]
  • BRN 1876367
  • Clodronate
  • Clodronic acid
  • Clodronsaeure
  • Dichlormethylen-bis(phosphonsaeure)
  • Dichloromethanediphosphonic acid
  • Dichloromethylidene diphosphonate
  • EINECS 234-212-1
  • Methanedichlorodiphosphonic acid
  • UNII-0813BZ6866

Systematic Names

  • Clodronic acid
  • Phosphonic acid, (dichloromethylene)bis-
  • Phosphonic acid, (dichloromethylene)di- (8CI)

Registry Numbers

CAS Registry Number

  • 10596-23-3

FDA UNII

  • 0813BZ6866

System Generated Number

  • 0010596233

Structure Descriptors

InChI

1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)

InChIKey

ACSIXWWBWUQEHA-UHFFFAOYSA-N

Smiles

C(P(O)(O)=O)(P(O)(O)=O)(Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LDLo oral 2500mg/kg (2500mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 266, Pg. 1691, 1993.
rat LDLo subcutaneous 1600mg/kg (1600mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 266, Pg. 1691, 1993.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 250 deg C   EXP
log P (octanol-water) 0.670 (none)   EST
Atmospheric OH Rate Constant 5.60E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.