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Substance Name: 4-Chloroaniline
RN: 106-47-8
UNII: Z553SGH315
InChIKey: QSNSCYSYFYORTR-UHFFFAOYSA-N

Molecular Formula

  • C6-H6-Cl-N

Molecular Weight

  • 127.5734
 

Classification Codes

Classification Codes

  • Mutation Data
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2B
  • Reportable Quantity (RQ) = 1000 lb

Names and Synonyms

Name of Substance

  • 4-Chloroaniline
  • p-Chloroaniline

Synonyms

  • 1-Amino-4-chlorobenzene
  • 4-Amino-1-chlorobenzene
  • 4-Aminochlorobenzene
  • 4-Chloranilin
  • 4-Chloranilin [Czech]
  • 4-Chloro-1-aminobenzene
  • 4-Chloroaniline
  • 4-Chlorobenzamine
  • 4-Chlorobenzenamine
  • 4-Chlorophenylamine
  • AI3-14908
  • Aniline, 4-chloro-
  • Aniline, p-chloro-
  • Benzenamine, 4-chloro-
  • Benzeneamine, 4-chloro
  • Caswell No. 182
  • CCRIS 131
  • EC 203-401-0
  • EINECS 203-401-0
  • EPA Pesticide Chemical Code 017203
  • HSDB 2047
  • NCI-C02039
  • NSC 36941
  • p-Aminochlorobenzene
  • p-CA
  • p-Chloraniline
  • p-Chloroaniline
  • p-Chlorophenylamine
  • RCRA waste number P024
  • UNII-Z553SGH315

Systematic Names

  • 4-Chloroaniline
  • 4-Chlorobenzeneamine
  • Aniline, p-chloro-
  • Benzenamine, 4-chloro-

Superlist Names

  • Aniline, p-chloro-
  • Benzenamine, 4-chloro-
  • p-Chloroaniline
  • para-Chloroaniline
  • RCRA waste no. P024

Registry Numbers

CAS Registry Number

  • 106-47-8

FDA UNII

  • Z553SGH315

Related Registry Numbers

  • 20265-96-7 (hydrochloride)
  • 4084-48-4 (BF3[1:1] salt)

System Generated Number

  • 0000106478

Structure Descriptors

InChI

1S/C6H6ClN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2

InChIKey

QSNSCYSYFYORTR-UHFFFAOYSA-N

Smiles

c1(ccc(Cl)cc1)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 100mg/kg (100mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat LD50 skin 239mg/kg (239mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(5), Pg. 29, 1969.
cat LDLo subcutaneous 125mg/kg (125mg/kg) BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Archiv fuer Hygiene und Bakteriologie. Vol. 110, Pg. 12, 1933.
dog LDLo intravenous 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 244, Pg. 387, 1963.
guinea pig LD50 oral 350mg/kg (350mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 34, 1982.
mouse LC12 inhalation 250mg/m3/6H (250mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 34, 1982.
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   Office of Toxic Substances Report. Vol. OTS,
mouse LD50 oral 100mg/kg (100mg/kg)   Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
quail LD50 oral 237mg/kg (237mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit LD50 skin 360mg/kg (360mg/kg) SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat LC50 inhalation 2340mg/m3/4H (2340mg/m3) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
National Technical Information Service. Vol. OTS0546450,
rat LD50 intraperitoneal 420mg/kg (420mg/kg)   Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 15, Pg. 447, 1957.
rat LD50 oral 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(7), Pg. 13, 1967.
rat LD50 skin 3200mg/kg (3200mg/kg)   Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 15, Pg. 447, 1957.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 72.5 deg C   EXP
Boiling Point 232 deg C   EXP
pKa Dissociation Constant 3.982 (none) 25 EXP
log P (octanol-water) 1.83 (none)   EXP
Water Solubility 3900 mg/L 25 EXP
Vapor Pressure 0.027 mm Hg 26 EXP
Henry's Law Constant 1.16E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.30E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.