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Substance Name: Epichlorohydrin
RN: 106-89-8
UNII: 08OOR508C0
InChIKey: BRLQWZUYTZBJKN-UHFFFAOYSA-N

Note

  • A chlorinated epoxy compound used as an industrial solvent. It is a strong skin irritant and carcinogen.

Molecular Formula

  • C3-H5-Cl-O

Molecular Weight

  • 92.5245
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Human Data
  • Insecticide
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2A
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 100 lb
  • Threshold Planning Quantity (TPQ) = 1000 lb
  • TWA (0.5 ppm); skin; Confirmed animal carcinogen with unknown relevance to humans
  • TWA 5 ppm (19 mg/m3); skin

Names and Synonyms

Name of Substance

  • Epichlorohydrin

MeSH Heading

  • Epichlorohydrin

Synonyms

  • (Chloromethyl)ethylene oxide
  • (Chloromethyl)oxirane
  • 1,2-Epoxy-3-chloropropane
  • 1-Chloor-2,3-epoxy-propaan
  • 1-Chloor-2,3-epoxy-propaan [Dutch]
  • 1-Chlor-2,3-epoxy-propan
  • 1-Chlor-2,3-epoxy-propan [German]
  • 1-Chloro-2,3-epoxypropane
  • 1-Cloro-2,3-epossipropano
  • 1-Cloro-2,3-epossipropano [Italian]
  • 2,3-Epoxypropyl chloride
  • 2-(Chloromethyl)oxirane
  • 3-Chloro-1,2-epoxypropane
  • 3-Chloro-1,2-propylene oxide
  • 3-Chloropropene-1,2-oxide
  • 3-Chloropropylene oxide
  • 5-17-01-00020 (Beilstein Handbook Reference)
  • AI3-03545
  • alpha-Epichlorohydrin
  • BRN 0079785
  • Caswell No. 424
  • CCRIS 277
  • Chloromethyloxirane
  • Chloropropylene oxide
  • EC 203-439-8
  • EINECS 203-439-8
  • EPA Pesticide Chemical Code 097201
  • epi-Chlorohydrin
  • Epichloorhydrine
  • Epichloorhydrine [Dutch]
  • Epichlorhydrin
  • Epichlorhydrine
  • Epichlorhydrine [French]
  • Epichlorohydrin
  • Epichlorohydryna
  • Epichlorohydryna [Polish]
  • Epichlorophydrin
  • Epicloridrina
  • Epicloridrina [Italian]
  • Glycerol epichlorhydrin
  • Glycerol epichlorohydrin
  • Glycidyl chloride
  • HSDB 39
  • NCI-C07001
  • NSC 6747
  • Oxirane, 2-(chloromethyl)
  • Propane, 1-chloro-2,3-epoxy-
  • RCRA waste number U041
  • Skekhg
  • UNII-08OOR508C0

Systematic Names

  • 1-Chloro-2,3-epoxypropane
  • Epichlorohydrin
  • Oxirane, (chloromethyl)-
  • Oxirane, 2-(chloromethyl)-
  • Propane, 1-chloro-2,3-epoxy-

Superlist Names

  • 1-Chloro-2,3-epoxypropane
  • Epichlorohydrin
  • Epichlorohydrin [UN2023] [Poison]
  • Oxirane, (chloromethyl)-
  • Propane, 1-chloro-2,3-epoxy-
  • RCRA waste no. U041
  • UN2023

Registry Numbers

CAS Registry Number

  • 106-89-8

FDA UNII

  • 08OOR508C0

Other Registry Numbers

  • 109351-74-8
  • 13403-37-7
  • 36250-81-4
  • 9009-12-5

System Generated Number

  • 0000106898

Structure Descriptors

InChI

1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2

InChIKey

BRLQWZUYTZBJKN-UHFFFAOYSA-N

Smiles

C1[C@@H](O1)CCl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 118mg/kg (118mg/kg)   Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972.
guinea pig LD50 oral 280mg/kg (280mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968.
human TCLo inhalation 20ppm (20ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
"Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968Vol. -, Pg. 108, 1968.
human TCLo inhalation 40ppm/2H (40ppm) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 240, 1969.
mouse LCLo inhalation 72gm/m3/9M (72000mg/m3)   Journal of Biomedical Materials Research. Vol. 8, Pg. 11, 1974.
mouse LD50 intraperitoneal 170mg/kg (170mg/kg)   Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972.
mouse LD50 oral 195mg/kg (195mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968.
mouse LD50 skin 250mg/kg (250mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 64, 1982.
mouse LDLo subcutaneous 250mg/kg (250mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BEHAVIORAL: MUSCLE WEAKNESS
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 2, Pg. 28, 1961.
rabbit LD50 intraperitoneal 160mg/kg (160mg/kg)   Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972.
rabbit LD50 oral 345mg/kg (345mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968.
rabbit LD50 skin 515mg/kg (515mg/kg)   Personal Communication from M.A. Wolf, Dow Chemical Co., Midland, MI 48640, Jan. 18, 1977Vol. 18JAN1977,
rat LC50 inhalation 250ppm/8H (250ppm)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 41, 1974.
rat LD50 intraperitoneal 113mg/kg (113mg/kg)   Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972.
rat LD50 intravenous 154mg/kg (154mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 41, 1974.
rat LD50 oral 90mg/kg (90mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 63, 1948.
rat LD50 subcutaneous 150mg/kg (150mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 28, Pg. 505, 1967.
rat LDLo skin 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
University of California, Berkeley, Publications in Pharmacology. Vol. 2, Pg. 69, 1941.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -5.72E+01 deg C   EXP
Boiling Point 116.11 deg C   EXP
log P (octanol-water) 0.45 (none)   EXP
Water Solubility 6.59E+04 mg/L 25 EXP
Vapor Pressure 16.4 mm Hg 25 EXP
Henry's Law Constant 3.04E-05 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.40E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.