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Substance Name: Ethylene dibromide [BSI:ISO]
RN: 106-93-4
UNII: 1N41638RNO
InChIKey: PAAZPARNPHGIKF-UHFFFAOYSA-N

Note

  • An effective soil fumigant, insecticide, and nematocide. In humans, it causes severe burning of skin and irritation of the eyes and respiratory tract. Prolonged inhalation may cause liver necrosis. It is also used in gasoline. Members of this group have caused liver and lung cancers in rodents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), 1,2-dibromoethane may reasonably be anticipated to be a carcinogen.

Molecular Formula

  • C2-H4-Br2

Molecular Weight

  • 187.862
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Fungicide, Bactericide, Wood Preservative
  • Human Data
  • Insecticide
  • Mutation Data
  • Nematocide
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 35
  • 2011 CERCLA Priority List, Rank: 39
  • Overall Carcinogenic Evaluation: Group 2A
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 1 lb
  • Skin; Confirmed Animal Carcinogen with Unknown Relevance to Humans
  • TWA 20 mg/m3; Ceiling 30 mg/m3, peak 50 mg/m3 in 5 min

Names and Synonyms

Results Name

  • Ethylene dibromide [BSI:ISO]

Name of Substance

  • Ethylene dibromide
  • Ethylene dibromide [BSI:ISO]

MeSH Heading

  • Ethylene dibromide

Synonyms

  • 1,2-Dibromaethan
  • 1,2-Dibromaethan [German]
  • 1,2-Dibromoetano
  • 1,2-Dibromoetano [Italian]
  • 1,2-Dibromoethane
  • 1,2-Dibroomethaan
  • 1,2-Dibroomethaan [Dutch]
  • 1,2-Ethylene dibromide
  • 4-01-00-00158 (Beilstein Handbook Reference)
  • Aadibroom
  • Aethylenbromid
  • Aethylenbromid [German]
  • AI3-15349
  • alpha,beta-Dibromoethane
  • alpha,omega-Dibromoethane
  • BRN 0605266
  • Bromofume
  • Bromuro di etile
  • Bromuro di etile [Italian]
  • Caswell No. 439
  • CCRIS 295
  • Celmide
  • Dibromure d'ethylene
  • Dibromure d'ethylene [French]
  • Dibromure d'ethylene [ISO-French]
  • Dowfume 40
  • Dowfume EDB
  • Dowfume W-100
  • Dowfume W-8
  • Dowfume W-85
  • Dowfume W-90
  • Dwubromoetan
  • Dwubromoetan [Polish]
  • E-D-Bee
  • EC 203-444-5
  • Edabrom
  • EDB
  • EDB-85
  • EINECS 203-444-5
  • ENT 15,349
  • EPA Pesticide Chemical Code 042002
  • Ethane, 1,2-dibromo-
  • Ethylene bromide
  • Ethylene dibromide
  • Fumo-gas
  • Glycol dibromide
  • HSDB 536
  • Iscobrome D
  • Kopfume
  • NCI-C00522
  • Nefis
  • Nephis
  • Pestmaster edb-85
  • RCRA waste number U067
  • Sanhyuum
  • Soilbrom
  • Soilbrom-100
  • Soilbrom-40
  • Soilbrom-85
  • Soilbrom-90
  • Soilbrom-90EC
  • Soilfume
  • sym-Dibromoethane
  • UN 1605
  • Unifume
  • UNII-1N41638RNO

Systematic Names

  • 1,2-Dibromoethane
  • Ethane, 1,2-dibromo-
  • Ethylene dibromide

Superlist Names

  • 1,2-Dibromoethane
  • Dibromoethane
  • EDB
  • Ethane, 1,2-dibromo-
  • Ethylene dibromide
  • Ethylene dibromide [UN1605] [Poison]
  • RCRA waste no. U067
  • UN1605

Registry Numbers

CAS Registry Number

  • 106-93-4

FDA UNII

  • 1N41638RNO

Other Registry Numbers

  • 56729-21-6
  • 625084-37-9
  • 8003-07-4

System Generated Number

  • 0000106934

Structure Descriptors

InChI

1S/C2H4Br2/c3-1-2-4/h1-2H2

InChIKey

PAAZPARNPHGIKF-UHFFFAOYSA-N

Smiles

C(CBr)Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 79mg/kg (79mg/kg)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LCLo inhalation 400ppm/3H (400ppm)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LCLo inhalation 400ppm/3H (400ppm) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"		 AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LD50 oral 110mg/kg (110mg/kg)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
man TDLo oral 43uL/kg (0.043mL/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"		 Human & Experimental Toxicology. Vol. 19, Pg. 152, 2000.
mouse LD50 intraperitoneal 220mg/kg (220mg/kg)   Journal fuer Praktische Chemie. Vol. 320, Pg. 133, 1978.
mouse LD50 unreported 146mg/kg (146mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 38, 1971.
mouse LDLo oral 250mg/kg (250mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.
quail LD50 oral 130mg/kg (130mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 British Poultry Science. Vol. 22, Pg. 355, 1981.
rabbit LD50 oral 55mg/kg (55mg/kg)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LD50 skin 300mg/kg (300mg/kg)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LD50 skin 300mg/kg (300mg/kg) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LDLo rectal 2500mg/kg (2500mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"		 Journal of Pharmacology and Experimental Therapeutics. Vol. 34, Pg. 223, 1928.
rat LC50 inhalation 14300mg/m3/30 (14300mg/m3) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Farmakologiya i Toksikologiya Vol. 8, Pg. 140, 1973.
rat LD50 oral 108mg/kg (108mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 17, 1978.
rat LD50 skin 300mg/kg (300mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
women LDLo oral 90mg/kg (90mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

GASTROINTESTINAL: NAUSEA OR VOMITING		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 257, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 9.9 deg C   EXP
Boiling Point 131.6 deg C   EXP
log P (octanol-water) 1.96 (none)   EXP
Water Solubility 3910 mg/L 25 EXP
Vapor Pressure 11.2 mm Hg 25 EXP
Henry's Law Constant 6.50E-04 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 2.50E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.