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Substance Name: Zidovudine sodium salt
RN: 106060-86-0
UNII: 8O1GL13IL5
InChIKey: XDTLRYHUHKZMKH-HNPMAXIBSA-M

Note

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

Molecular Formula

  • C10-H13-N5-O4.Na

Molecular Weight

  • 289.2258
 
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Names and Synonyms

Results Name

  • Zidovudine sodium salt

Name of Substance

  • Zidovudine sodium salt

Synonyms

  • UNII-8O1GL13IL5
  • Zidovudine sodium salt

Systematic Name

  • Thymidine, 3'-azido-3'-deoxy-, monosodium salt

Registry Numbers

CAS Registry Number

  • 106060-86-0

FDA UNII

  • 8O1GL13IL5

System Generated Number

  • 0106060860

Molecular Formulas

Molecular Formula

  • C10-H13-N5-O4.Na

Molecular Formula Fragments

  • C10-H13-N5-O4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C10H13N5O4.Na/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8;/h3,6-8,16H,2,4H2,1H3,(H,12,17,18);/q;+1/p-1/t6-,7+,8+;/m0./s1

InChIKey

XDTLRYHUHKZMKH-HNPMAXIBSA-M

Smiles

Cc1cn(c(=O)[n-]c1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-].[Na+]