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Substance Name: Basic fibroblast growth factor (bFGF)
RN: 106096-93-9
UNII: S3529G9M9V

Note

  • A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor ( FIBROBLAST GROWTH FACTOR 1).
 

Classification Code

  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Basic fibroblast growth factor (bFGF)

Synonyms

  • Basic astrolial growth factor
  • Basic FGF
  • Basic fibroblast growth factor
  • Basic fibroblast growth factor, recombinant human, KCB-1
  • CCRIS 8682
  • FCE 26184
  • FGF 2
  • Fibroblast growth factor, basic
  • Heparin-binding growth factor 2
  • KCB-1
  • Recombinant human basic fibroblast growth factor, KCB-1
  • UNII-S3529G9M9V

Systematic Names

  • Fibroblast growth factor, basic
  • Fibroblast growth factor, basic, recombinant human, KCB-1

Registry Numbers

CAS Registry Number

  • 106096-93-9

FDA UNII

  • S3529G9M9V

System Generated Number

  • 0106096939

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD intramuscular > 40mg/kg (40mg/kg) BLOOD: CHANGES IN SPLEEN

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Kiso to Rinsho. Clinical Report. Vol. 30, Pg. 1605, 1996.
rat LD intravenous > 20mg/kg (20mg/kg) BLOOD: CHANGES IN SPLEEN Kiso to Rinsho. Clinical Report. Vol. 30, Pg. 1605, 1996.
rat LD subcutaneous > 80mg/kg (80mg/kg) BLOOD: CHANGES IN SPLEEN

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Kiso to Rinsho. Clinical Report. Vol. 30, Pg. 1605, 1996.