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Substance Name: Risperidone [USAN:USP:INN:BAN]
RN: 106266-06-2
UNII: L6UH7ZF8HC
InChIKey: RAPZEAPATHNIPO-UHFFFAOYSA-N
Note
- A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
Molecular Formula
- C23-H27-F-N4-O2
Molecular Weight
- 410.4903
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Drug / Therapeutic Agent
- Human Data
- Neuroleptic
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Serotonin Agents
- Serotonin Antagonists
- Tranquilizing Agents
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Risperidone
- Risperidone [USAN:USP:INN:BAN]
MeSH Heading
- Risperidone
Synonyms
- 3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one
- Apexidone
- BRN 4891881
- HSDB 7580
- NSC 759895
- Psychodal
- R 64 766
- R 64,766
- R 64766
- Risperdal
- Risperdal Consta
- Risperidal M-Tab
- Risperidona
- Risperidona [Spanish]
- Risperidone
- Risperidonum
- Risperidonum [Latin]
- Risperin
- Rispolept
- Rispolin
- Sequinan
- Spiron
- UNII-L6UH7ZF8HC
- Zophrenal
Systematic Names
- 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-
- 4H-Pyrido(1,2-a)pyrimidin-4-one, 6,7,8,9-tetrahydro-3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-2-methyl-
Registry Numbers
CAS Registry Number
- 106266-06-2
FDA UNII
- L6UH7ZF8HC
System Generated Number
- 0106266062
Structure Descriptors
InChI
InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3InChIKey
RAPZEAPATHNIPO-UHFFFAOYSA-NSmiles
CC1=C(CCN2CCC(CC2)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 268ug/kg (0.268mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Annals of Pharmacotherpy. Vol. 30, Pg. 360, 1996. |
dog | LD50 | intravenous | 14100ug/kg (14.1mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988. | |
dog | LD50 | oral | 18300ug/kg (18.3mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: MUSCLE WEAKNESS | Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993. |
man | TDLo | oral | 114ug/kg/2D-I (0.114mg/kg) | BEHAVIORAL: WAKEFULNESS BEHAVIORAL: EUPHORIA BEHAVIORAL: EXCITEMENT | American Journal of Psychiatry. Vol. 153, Pg. 1234, 1996. |
man | TDLo | oral | 429ug/kg (0.429mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE | American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998. |
man | TDLo | oral | 429ug/kg/15D- (0.429mg/kg) | BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING | Journal of Clinical Psychiatry. Vol. 58, Pg. 323, 1997. |
man | TDLo | oral | 3428ug/kg (3.428mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | Annals of Emergency Medicine. Vol. 22, Pg. 1908, 1993. |
man | TDLo | oral | 3857ug/kg (3.857mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 893, 1999. |
mouse | LD50 | intravenous | 26900ug/kg (26.9mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988. | |
mouse | LD50 | oral | 63100ug/kg (63.1mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988. | |
rat | LD50 | intravenous | 34300ug/kg (34.3mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993. |
rat | LD50 | oral | 56600ug/kg (56.6mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988. | |
rat | LD50 | subcutaneous | 98mg/kg (98mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993. |
women | TDLo | oral | 400ug/kg (0.4mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998. |
women | TDLo | oral | 880ug/kg (0.88mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998. |
women | TDLo | oral | 1840ug/kg (1.84mg/kg) | BEHAVIORAL: HEADACHE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Journal of Clinical Psychiatry. Vol. 56, Pg. 514, 1995. |
women | TDLo | oral | 2mg/kg (2mg/kg) | VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Journal of Clinical Pyschopharmacology. Vol. 17, Pg. 325, 1997. |
women | TDLo | oral | 2200ug/kg (2.2mg/kg) | Therapie. Vol. 52, Pg. 155, 1997. | |
women | TDLo | oral | 2200ug/kg (2.2mg/kg) | VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Therapie. Vol. 52, Pg. 155, 1997. |
women | TDLo | oral | 648mg/kg/77W- (648mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Journal of Clinical Psychiatry. Vol. 59, Pg. 478, 1998. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 170 | deg C | EXP | |
log P (octanol-water) | 3.490 | (none) | EST | |
Atmospheric OH Rate Constant | 1.53E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.