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Substance Name: Poloxamer [USAN:INN:BAN]
RN: 106392-12-5

Note

  • A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)

Molecular Formula

  • (C2-H4-O.C3-H6-O)x-

Molecular Weight

  • 102.132
 

Classification Codes

  • Drug / Therapeutic Agent
  • Excipients
  • Pharmaceutic Aid (Ointment Base)
  • Pharmaceutic Aid (Suppository Base)
  • Pharmaceutic Aid (Surfactant)
  • Pharmaceutic Aid (Tablet Binder and Emulsifying Agent)
  • Pharmaceutic Aids
  • Pharmaceutical Vehicles
  • Skin / Eye Irritant
  • Surface-Active Agents
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Links to Resources

Names and Synonyms

Name of Substance

  • Poloxamer
  • Poloxamer [USAN:INN:BAN]

MeSH Heading

  • Poloxamer

Synonyms

  • Adeka 25R1
  • Adeka 25R2
  • Adeka L 61
  • Adeka Pluronic F 108
  • alpha-Hydro-omega-hydroxypoly(oxyethylene)(sub a)-poly(oxopropylene)(sub b)-poly(oxyethylene)(sub a) block copolymer
  • Antarox 17R4
  • Antarox 25R2
  • Antarox B 25
  • Antarox F 108
  • Antarox F 68
  • Antarox F 88
  • Antarox F 88FL
  • Antarox L 61
  • Antarox L 72
  • Antarox P 104
  • Antarox P 84
  • Antarox SC 138
  • Arco Polyol R 2633
  • Arcol E 351
  • B 053
  • BASF-L 101
  • Block polyethylene-polypropylene glycol
  • Block polyoxyethylene-polyoxypropylene
  • Breox BL 19-10
  • Cirrasol ALN-WS
  • Crisvon Assistor SD 14
  • CRL 1005
  • CRL 1605
  • CRL 8131
  • CRL 8142
  • D 500 (polyglycol)
  • Daltocel F 460
  • Dehypon KE 3557
  • Detalan
  • Empilan P 7068
  • Emulgen PP 230
  • Epan 450
  • Epan 485
  • Epan 710
  • Epan 785
  • Epan U 108
  • Ethylene glycol-propylene glycol block copolymer
  • Ethylene oxide-propylene oxide block copolymer dipropylene glycol ether
  • Ethylene oxide-propylene oxide block copolymer ether with ethylene glycol
  • Ethylene oxide-propylene oxide block polymer
  • F 108
  • F 127
  • F 77
  • F 87
  • F 88
  • Lutrol F
  • Methyloxirane polymer with oxirane block
  • P 103
  • P 104
  • P 105
  • P 123
  • P 65
  • P 84
  • P 85
  • Pluracare
  • Pluronic
  • Pluronic L 61
  • Poloxamer
  • Poloxamer 188
  • Polyoxamer 108
  • Polyoxypropylene-polyoxyethylene block copolymer
  • Propylene oxide ethylene oxide block polymer
  • Slovanik M-640
  • Tergitol nonionic XH

Systematic Names

  • alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene)a block copolymer
  • Oxirane, methyl-, polymer with oxirane
  • Oxirane, methyl-, polymer with oxirane, block
  • Pluronic F 38
  • Pluronic F108
  • Pluronic F127
  • Pluronic F68
  • Pluronic F77
  • Pluronic F87
  • Pluronic F88
  • Pluronic L-81
  • Pluronic L44
  • Pluronic L62
  • Pluronic L64
  • Pluronic P103
  • Pluronic P104
  • Pluronic P105
  • Pluronic P123
  • Pluronic P65
  • Pluronic P84
  • Pluronic P85
  • Poloxamer-188
  • Tergitol XH

Superlist Name

  • Polyoxyethylene - polyoxypropylene block copolymer

Registry Numbers

CAS Registry Number

  • 106392-12-5

Other Registry Number

  • 11104-97-5

System Generated Number

  • 0106392125

Molecular Formulas

Molecular Formula

  • (C2-H4-O.C3-H6-O)x-

Molecular Formula Fragments

  • C2-H4-O
  • C3-H6-O
  • COMPONENT

Structure Descriptors

Smiles

C1[C@@H](O1)C.C1CO1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 420mg/kg (420mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
mouse LD50 intravenous 129mg/kg (129mg/kg)   Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 569, 1993.
mouse LD50 intravenous 1gm/kg (1000mg/kg)   Microvascular Research. Vol. 8, Pg. 320, 1974.
mouse LD50 intravenous 3gm/kg (3000mg/kg)   Drugs in Japan Vol. 6, Pg. 797, 1982.
mouse LD50 oral > 30300ug/kg (30.3mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981.
mouse LD50 oral 1830mg/kg (1830mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
mouse LD50 oral 15gm/kg (15000mg/kg)   Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962.
mouse LD50 subcutaneous 5500mg/kg (5500mg/kg)   Drugs in Japan Vol. 6, Pg. 797, 1982.
mouse LD50 unreported 400mg/kg (400mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 530mg/kg (530mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 750mg/kg (750mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 830mg/kg (830mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 1250mg/kg (1250mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 1400mg/kg (1400mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 2250mg/kg (2250mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 2700mg/kg (2700mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 3gm/kg (3000mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 3750mg/kg (3750mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 4200mg/kg (4200mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #4043344,
rabbit LD50 skin > 5gm/kg (5000mg/kg)   Union Carbide Data Sheet. Vol. 7/14/1965,
rat LD50 intraperitoneal 320mg/kg (320mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES

BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0540972,
rat LD50 intraperitoneal 1140mg/kg (1140mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
rat LD50 intravenous 7500mg/kg (7500mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
rat LD50 oral > 30300ug/kg (30.3mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981.
rat LD50 oral 2300mg/kg (2300mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
rat LD50 oral 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
Wyandotte Chemicals Corporation Reports.
rat LD50 oral 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Wyandotte Chemicals Corporation Reports.
rat LD50 oral 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Wyandotte Chemicals Corporation Reports.
rat LD50 oral 9380mg/kg (9380mg/kg)   "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 297, 1972.
rat LD50 oral 22400mg/kg (22400mg/kg)   Union Carbide Data Sheet. Vol. 7/14/1965,
rat LD50 subcutaneous 6900mg/kg (6900mg/kg)   Drugs in Japan Vol. 6, Pg. 797, 1982.