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Substance Name: Tamsulosin hydrochloride [USAN:USP:JAN]
RN: 106463-17-6
UNII: 11SV1951MR
InChIKey: ZZIZZTHXZRDOFM-XFULWGLBSA-N

Note

  • An alpha 1 adrenoreceptor blocker; approved for treatment of benign prostatic hyperplasia; floppy iris syndrome during cataract surgery has been noted.

Molecular Formula

  • C20-H28-N2-O5-S.Cl-H

Molecular Weight

  • 444.9771
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic Antagonists
  • Antineoplastic Agents
  • Benign Prostatic Hyperplasia Therapy Agent
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Tamsulosin hydrochloride [USAN:USP:JAN]
  • YM 617

Synonyms

  • (-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochloride
  • (-)-LY 253352
  • Alna
  • Amsulosin hydrochloride
  • Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, monohydrochloride, (R)-
  • Expros
  • Flomax
  • Josir
  • LY253351
  • Omic
  • Omix
  • Omnic
  • Pradif
  • R-(-)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochloride
  • R-(-)-YM-12617
  • Secotex
  • Tamsulosin HCl
  • Tamsulosin hydrochloride
  • UNII-11SV1951MR
  • Urolosin
  • YM-12617-1
  • YM617

Systematic Name

  • Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, monohydrochloride, (R)-

Registry Numbers

CAS Registry Number

  • 106463-17-6

FDA UNII

  • 11SV1951MR

Other Registry Numbers

  • 112101-78-7
  • 128332-25-2

Related Registry Number

  • 106138-88-9 (Parent)

System Generated Number

  • 0106463176

Molecular Formulas

Molecular Formula

  • C20-H28-N2-O5-S.Cl-H

Molecular Formula Fragments

  • C20-H28-N2-O5-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

InChIKey

ZZIZZTHXZRDOFM-XFULWGLBSA-N

Smiles

Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(=O)(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5085, 1990.
mouse LD50 intravenous 98mg/kg (98mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
mouse LD50 oral 1023mg/kg (1023mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
mouse LD50 subcutaneous 254mg/kg (254mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
rat LD50 intravenous 70mg/kg (70mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.
rat LD50 oral 650mg/kg (650mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.
rat LD50 subcutaneous 347mg/kg (347mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.