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Substance Name: Tafenoquine succinate [USAN]
RN: 106635-81-8
UNII: DL5J0B8VSS
InChIKey: CQBKFGJRAOXYIP-UHFFFAOYSA-N

Classification Codes

  • Anti-Infective Agents
  • Antimalarials
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H28-F3-N3-O3.C4-H6-O4

Molecular Weight

  • 581.5846
 
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Names and Synonyms

Name of Substance

  • Tafenoquine succinate [USAN]

Synonyms

  • Tafenoquine succinate
  • UNII-DL5J0B8VSS
  • WR 238605
  • WR238605 succinate

Systematic Name

  • Butanedioic acid, compd. with N(sup 4)-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine (1:1)

Registry Numbers

CAS Registry Number

  • 106635-81-8

FDA UNII

  • DL5J0B8VSS

Related Registry Number

  • 106635-80-7 (Parent)

System Generated Number

  • 0106635818

Molecular Formulas

Molecular Formula

  • C24-H28-F3-N3-O3.C4-H6-O4

Molecular Formula Fragments

  • C24-H28-F3-N3-O3
  • C4-H6-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C24H28F3N3O3.C4H6O4/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27;5-3(6)1-2-4(7)8/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3;1-2H2,(H,5,6)(H,7,8)

InChIKey

CQBKFGJRAOXYIP-UHFFFAOYSA-N

Smiles

Cc1cc(nc2c1c(c(cc2NC(C)CCCN)OC)Oc3cccc(c3)C(F)(F)F)OC.C(CC(=O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intraperitoneal 71mg/kg (71mg/kg)   Journal of Medicinal Chemistry. Vol. 32, Pg. 1728, 1989.
rat LD50 oral 416mg/kg (416mg/kg)   Journal of Medicinal Chemistry. Vol. 32, Pg. 1728, 1989.