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Substance Name: Valproate sodium [USAN:USP]
RN: 1069-66-5
UNII: 5VOM6GYJ0D
InChIKey: AEQFSUDEHCCHBT-UHFFFAOYSA-M
Note
- A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
Molecular Formulas
- C8-H15-Na-O2
- C8-H15-O2.Na
- C8-H16-O2.Na
Molecular Weight
- 166.1945
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anticonvulsant
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Valproate sodium [USAN:USP]
Synonyms
- 2-Propylpentanoic acid sodium salt
- 2-Propylvaleric acid sodium salt
- Abbott 44090
- Convulex
- Depacon
- Depakene
- Dipropylacetate sodium
- EINECS 213-961-8
- Epilim
- Eurekene
- KW 6066N
- Labazene
- Natrium valproat
- Orfiril
- Pentanoic acid, 2-propyl-, sodium salt
- Sodium 2-n-propyl-pentanoate
- Sodium 2-propylpentanoate
- Sodium 2-propylvalerate
- Sodium bispropylacetate
- Sodium dipropylacetate
- Sodium n-dipropylacetate
- Sodium valproate
- UNII-5VOM6GYJ0D
- Valerin
- Valproate sodium
- Valproic acid sodium salt
- Valproic acid sodium salt (1:1)
- Valproinsaeure, natrium
Systematic Names
- Pentanoic acid, 2-propyl-, sodium salt
- Sodium valproate
- Valeric acid, 2-propyl-, sodium salt
Registry Numbers
CAS Registry Number
- 1069-66-5
FDA UNII
- 5VOM6GYJ0D
System Generated Number
- 0001069665
Molecular Formulas
Molecular Formulas
- C8-H15-Na-O2
- C8-H15-O2.Na
- C8-H16-O2.Na
Molecular Formula Fragments
- C8-H15-O2
- C8-H16-O2
- COMPONENT
- Na
Structure Descriptors
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1InChIKey
AEQFSUDEHCCHBT-UHFFFAOYSA-MSmiles
C(CCC)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intraperitoneal | 565mg/kg (565mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 13, Pg. 81, 1977. | |
child | LDLo | oral | 750mg/kg (750mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: OTHER CHANGES BEHAVIORAL: COMA | Lancet. Vol. 1, Pg. 221, 1984. |
child | TDLo | oral | 1820mg/kg/12W (1820mg/kg) | BEHAVIORAL: SLEEP GASTROINTESTINAL: NAUSEA OR VOMITING | Lancet. Vol. 2, Pg. 1110, 1980. |
dog | LD50 | intraperitoneal | 700mg/kg (700mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 58, 1979. |
dog | LD50 | oral | 1420mg/kg (1420mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 58, 1979. |
guinea pig | LD50 | oral | 824mg/kg (824mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 58, 1979. |
hamster | LD50 | oral | 1740mg/kg (1740mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 58, 1979. |
infant | LDLo | oral | 250mg/kg/10D- (250mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS BLOOD: HEMORRHAGE | Archives of Disease in Childhood. Vol. 58, Pg. 543, 1983. |
man | TDLo | oral | 17mg/kg (17mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LIVER: LIVER FUNCTION TESTS IMPAIRED | Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 209, 1992. |
man | TDLo | oral | 214mg/kg/30D- (214mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" | Israel Journal of Medical Sciences. Vol. 30, Pg. 283, 1994. |
mouse | LD50 | intramuscular | 832mg/kg (832mg/kg) | Biochemical Pharmacology. Vol. 22, Pg. 1701, 1973. | |
mouse | LD50 | intraperitoneal | 470mg/kg (470mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 58, 1979. |
mouse | LD50 | intravenous | 750mg/kg (750mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 299, 1976. |
mouse | LD50 | oral | 977mg/kg (977mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 25, Pg. 71, 1990. | |
mouse | LD50 | subcutaneous | 860mg/kg (860mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 58, 1979. |
mouse | LD50 | unreported | 1700mg/kg (1700mg/kg) | United States Patent Document. Vol. #3301754, | |
rabbit | LD50 | intraperitoneal | 1200mg/kg (1200mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 13, Pg. 81, 1977. | |
rabbit | LD50 | oral | 1468mg/kg (1468mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 41, 1971. | |
rat | LD50 | intraperitoneal | 970mg/kg (970mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 58, 1979. |
rat | LD50 | intravenous | 509mg/kg (509mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1155, 1983. | |
rat | LD50 | oral | 670mg/kg (670mg/kg) | British Journal of Pharmacology. Vol. 74, Pg. 957P, 1981. | |
rat | LD50 | subcutaneous | 1029mg/kg (1029mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 41, 1971. | |
women | TDLo | oral | 500mg/kg (500mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SLEEP | Postgraduate Medical Journal. Vol. 62, Pg. 409, 1986. |
women | TDLo | oral | 1040mg/kg (1040mg/kg) | BLOOD: THROMBOCYTOPENIA BEHAVIORAL: COMA BRAIN AND COVERINGS: CHANGES IN SURFACE EEG | Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 279, 1995. |