|
|
|
Substance Name: Adefovir [USAN:INN:BAN]
RN: 106941-25-7
UNII: 6GQP90I798
InChIKey: SUPKOOSCJHTBAH-UHFFFAOYSA-N
Note
- Inhibitor of African swine fever virus.
Molecular Formula
- C8-H12-N5-O4-P
Molecular Weight
- 273.1878
Classification Codes
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antiviral
- Antiviral Agents
- Enzyme Inhibitors
- Mutation Data
- Nucleic Acid Synthesis Inhibitors
- Reverse Transcriptase Inhibitors
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Adefovir
- Adefovir [USAN:INN:BAN]
Synonyms
- ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
- 9-(2-(Phosphonomethoxy)ethyl)adenine
- 9-(2-Phosphonylmethoxyethyl)adenine
- Adefovir
- BRN 3561094
- DRG-0156
- GS 0393
- GS 393
- GS-0393
- HSDB 8079
- N-(2-Phophonomethoxyethyl-2,6-diaminopurine)
- N-(2-Phosphonylmethoxyethyl)adenine
- Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)-
- PMEA
- UNII-6GQP90I798
Systematic Name
- Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)-
Registry Numbers
CAS Registry Number
- 106941-25-7
FDA UNII
- 6GQP90I798
System Generated Number
- 0106941257
Structure Descriptors
InChI
InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)InChIKey
SUPKOOSCJHTBAH-UHFFFAOYSA-NSmiles
Nc1ncnc2c1ncn2CCOCP(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD | intravenous | > 1gm/kg (1000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Antimicrobial Agents and Chemotherapy. Vol. 40, Pg. 1072, 1996. |
| mouse | LDLo | intraperitoneal | 1600mg/kg (1600mg/kg) | Antimicrobial Agents and Chemotherapy. Vol. 40, Pg. 1072, 1996. |