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Substance Name: Adefovir [USAN:INN:BAN]
RN: 106941-25-7
UNII: 6GQP90I798
InChIKey: SUPKOOSCJHTBAH-UHFFFAOYSA-N

Note

  • Inhibitor of African swine fever virus.

Molecular Formula

  • C8-H12-N5-O4-P

Molecular Weight

  • 273.1878
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral Agents
  • Enzyme Inhibitors
  • Mutation Data
  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors

Names and Synonyms

Name of Substance

  • Adefovir
  • Adefovir [USAN:INN:BAN]

Synonyms

  • ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
  • 9-(2-(Phosphonomethoxy)ethyl)adenine
  • 9-(2-Phosphonylmethoxyethyl)adenine
  • Adefovir
  • BRN 3561094
  • DRG-0156
  • GS 0393
  • GS 393
  • GS-0393
  • HSDB 8079
  • N-(2-Phophonomethoxyethyl-2,6-diaminopurine)
  • N-(2-Phosphonylmethoxyethyl)adenine
  • Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)-
  • PMEA
  • UNII-6GQP90I798

Systematic Name

  • Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)-

Registry Numbers

CAS Registry Number

  • 106941-25-7

FDA UNII

  • 6GQP90I798

System Generated Number

  • 0106941257

Structure Descriptors

InChI

1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)

InChIKey

SUPKOOSCJHTBAH-UHFFFAOYSA-N

Smiles

c1nc(c2c(n1)n(cn2)CCOCP(=O)(O)O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intravenous > 1gm/kg (1000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Antimicrobial Agents and Chemotherapy. Vol. 40, Pg. 1072, 1996.
mouse LDLo intraperitoneal 1600mg/kg (1600mg/kg)   Antimicrobial Agents and Chemotherapy. Vol. 40, Pg. 1072, 1996.