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Substance Name: 2-Chloroethanol
RN: 107-07-3
UNII: 753N66IHAN
InChIKey: SZIFAVKTNFCBPC-UHFFFAOYSA-N

Note

  • Used as a solvent, in the manufacture of insecticides, and for treating sweet potatoes before planting. May cause nausea, vomiting, pains in head and chest, stupefaction. Irritates mucous membranes and causes kidney and liver degeneration.

Molecular Formula

  • C2-H5-Cl-O

Molecular Weight

  • 80.5135
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Ceiling (1 ppm); skin; Not classifiable as a human carcinogen
  • Threshold Planning Quantity (TPQ) = 500 lb
  • TWA 5 ppm (16 mg/m3); skin

Names and Synonyms

Name of Substance

  • 2-Chloroethanol
  • Ethylene chlorohydrin

MeSH Heading

  • Ethylene chlorohydrin

Synonyms

  • 2-Chloorethanol
  • 2-Chloorethanol [Dutch]
  • 2-Chloraethanol
  • 2-Chloraethanol [German]
  • 2-Chlorethanol
  • 2-Chlorethanol [German]
  • 2-Chloro-1-ethanol
  • 2-Chloro-1-hydroxyethane
  • 2-Chloroethanol
  • 2-Chloroethyl alcohol
  • 2-Cloroetanolo
  • 2-Cloroetanolo [Italian]
  • 2-Hydroxyethyl chloride
  • 2-Monochloroethanol
  • 4-01-00-01372 (Beilstein Handbook Reference)
  • Aethylenechlorhydrin
  • Aethylenechlorhydrin [German]
  • AI3-52326
  • beta-Chloroethyl alcohol
  • beta-Hydroxyethyl chloride
  • BRN 0878139
  • CCRIS 859
  • Chloroethylowy alkohol
  • Chloroethylowy alkohol [Polish]
  • delta-Chloroethanol
  • delta-Chloroethanolchloroethylowy alkohol
  • delta-Chloroethanolchloroethylowy alkohol [Polish]
  • EC 203-459-7
  • EINECS 203-459-7
  • Ethanol, 2-chloro-
  • Ethene, chlorohydrin
  • Ethylchlorohydrin
  • Ethyleen-chloorhydrine
  • Ethyleen-chloorhydrine [Dutch]
  • Ethylene chlorhydrin
  • Ethylene chlorohydrin
  • Ethylene glycol, chlorohydrin
  • Glicol monocloridrina
  • Glicol monocloridrina [Italian]
  • Glycol chlorohydrin
  • Glycol monochlorohydrin
  • Glycolmonochloorhydrine
  • Glycolmonochloorhydrine [Dutch]
  • Glycomonochlorhydrin
  • HSDB 426
  • Monochlorhydrine du glycol
  • Monochlorhydrine du glycol [French]
  • NCI-C50135
  • NSC 122289
  • UNII-753N66IHAN

Systematic Names

  • 2-Chloroethanol
  • Ethanol, 2-chloro-

Superlist Names

  • 2-Chloroethanol
  • Chloroethanol
  • Ethanol, 2-chloro-
  • Ethylene chlorohydrin
  • Ethylene chlorohydrin [UN1135] [Poison]
  • UN1135

Registry Numbers

CAS Registry Number

  • 107-07-3

FDA UNII

  • 753N66IHAN

Other Registry Numbers

  • 1253945-55-9
  • 1867-09-0

System Generated Number

  • 0000107073

Structure Descriptors

InChI

1S/C2H5ClO/c3-1-2-4/h4H,1-2H2

InChIKey

SZIFAVKTNFCBPC-UHFFFAOYSA-N

Smiles

C(CCl)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo subcutaneous 250mg/kg (250mg/kg)   British Journal of Industrial Medicine. Vol. 1, Pg. 207, 1944.
guinea pig LC50 inhalation 870mg/m3 (870mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 54, 1971.
guinea pig LD50 intraperitoneal 85mg/kg (85mg/kg)   Journal of Pharmaceutical Sciences. Vol. 61, Pg. 19, 1972.
guinea pig LD50 oral 110mg/kg (110mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig LD50 subcutaneous 75mg/kg (75mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 54, 1971.
guinea pig LDLo skin 70mg/kg (70mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 93, 1945.
man LCLo inhalation 305ppm/2H (305ppm) LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 277, 1944.
mouse LC50 inhalation 385mg/m3 (385mg/m3) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 36(4-6), Pg. 376, 1971.
mouse LD50 intraperitoneal 97mg/kg (97mg/kg)   Journal of Pharmaceutical Sciences. Vol. 61, Pg. 19, 1972.
mouse LD50 oral 81mg/kg (81mg/kg)   Journal of Pharmaceutical Sciences. Vol. 60, Pg. 568, 1971.
mouse LD50 skin 18mg/kg (18mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.
mouse LD50 subcutaneous 98mg/kg (98mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 54, 1971.
mouse LD50 unreported 91mg/kg (91mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(8), Pg. 13, 1978.
rabbit LD50 intraperitoneal 80mg/kg (80mg/kg)   Journal of Pharmaceutical Sciences. Vol. 61, Pg. 19, 1972.
rabbit LD50 skin 67mg/kg (67mg/kg)   Journal of Pharmaceutical Sciences. Vol. 61, Pg. 19, 1972.
rabbit LD50 subcutaneous 100mg/kg (100mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 54, 1971.
rabbit LDLo intravenous 100mg/kg (100mg/kg) CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
British Journal of Industrial Medicine. Vol. 1, Pg. 207, 1944.
rat LC50 inhalation 290mg/m3 (290mg/m3) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 36(4-6), Pg. 376, 1971.
rat LD50 oral 71mg/kg (71mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Hygiene and Sanitation Vol. 36(4-6), Pg. 376, 1971.
rat LD50 skin 293mg/kg (293mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-275, Pg. 1985,
rat LD50 subcutaneous 84mg/kg (84mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 36(4-6), Pg. 376, 1971.
rat LD50 unreported 71mg/kg (71mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(8), Pg. 13, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -6.75E+01 deg C   EXP
Boiling Point 128.6 deg C   EXP
pKa Dissociation Constant 14.31 (none)   EXP
log P (octanol-water) 0.03 (none)   EXP
Water Solubility 1.00E+06 mg/L 20 EXP
Vapor Pressure 7.18 mm Hg 25 EXP
Henry's Law Constant 7.61E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.40E-12 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.