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Substance Name: Ethylene glycol
RN: 107-21-1
UNII: FC72KVT52F
InChIKey: LYCAIKOWRPUZTN-UHFFFAOYSA-N
Note
- A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.
Molecular Formula
- C2-H6-O2
Molecular Weight
- 62.0674
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Agricultural Chemical
- Human Data
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
- Unspecified / Unclassified Pesticide
Superlist Classification Codes
- Ceiling 100 mg/m3 aerosol only; Not classifiable as a human carcinogen
- Reportable Quantity (RQ) = 5000 lb
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Names and Synonyms
Name of Substance
- 1,2-Ethanediol
- Ethylene glycol
- Glycol
MeSH Heading
- Ethylene glycol
Synonyms
- 1,2-Dihydroxyethane
- 1,2-Ethanediol
- 146AR
- 2-Hydroxyethanol
- Aethylenglykol
- Aethylenglykol [German]
- AI3-03050
- Caswell No. 441
- CCRIS 3744
- Dowtherm SR 1
- EC 203-473-3
- EINECS 203-473-3
- EPA Pesticide Chemical Code 042203
- Ethylene alcohol
- Ethylene dihydrate
- Ethylene glycol
- Fridex
- Glycol
- Glycol alcohol
- Glycol, ethylene-
- HSDB 5012
- Lutrol-9
- Macrogol 400 BPC
- Monoethylene glycol
- NCI-C00920
- Norkool
- NSC 93876
- Ramp
- Tescol
- Ucar 17
- UNII-FC72KVT52F
- Union Carbide XL 54 Type I De-icing Fluid
- Zerex
Systematic Names
- 1,2-Ethanediol
- Ethane-1,2-diol
- Ethylene glycol
Superlist Names
- 1,2-Ethanediol
- Ethylene glycol
- Glycol
Registry Numbers
CAS Registry Number
- 107-21-1
FDA UNII
- FC72KVT52F
Other Registry Numbers
- 1371582-33-0
- 2088100-90-5
- 37221-95-7
- 71767-64-1
System Generated Number
- 0000107211
Structure Descriptors
InChI
InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2InChIKey
LYCAIKOWRPUZTN-UHFFFAOYSA-NSmiles
OCCOToxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | oral | 1650mg/kg (1650mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978. |
cat | LDLo | subcutaneous | 2gm/kg (2000mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BLOOD: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933. |
child | TDLo | oral | 5500mg/kg (5500mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: GENERAL ANESTHETIC KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Postgraduate Medical Journal. Vol. 52, Pg. 598, 1976. |
dog | LD50 | oral | 5500mg/kg (5500mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978. |
guinea pig | LD50 | oral | 6610mg/kg (6610mg/kg) | GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. |
guinea pig | LD50 | unreported | 11150mg/kg (11150mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968. |
guinea pig | LDLo | subcutaneous | 5gm/kg (5000mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 51, Pg. 398, 1935. | |
human | LDLo | oral | 398mg/kg (398mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: HEADACHE LIVER: OTHER CHANGES | Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. Vol. 26(2), Pg. 48, 1983. |
human | LDLo | oral | 786mg/kg (786mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: COMA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 373, 1976. |
human | TCLo | inhalation | 10000mg/m3 (10000mg/m3) | LUNGS, THORAX, OR RESPIRATION: COUGH SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933. |
man | LDLo | unreported | 1637mg/kg (1637mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TDLo | oral | 1195mg/kg (1195mg/kg) | KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE | Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991. |
man | TDLo | oral | 15gm/kg (15000mg/kg) | KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE | Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991. |
man | TDLo | oral | 16gm/kg (16000mg/kg) | KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED BEHAVIORAL: COMA | Human & Experimental Toxicology. Vol. 9, Pg. 317, 1990. |
man | TDLo | oral | 24gm/kg (24000mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 445, 2000. |
mouse | LC | inhalation | > 200mg/m3/2H (200mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981. | |
mouse | LD50 | intraperitoneal | 5614mg/kg (5614mg/kg) | KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI BLOOD: CHANGES IN SPLEEN LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947. |
mouse | LD50 | intravenous | 3gm/kg (3000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939. | |
mouse | LD50 | oral | 5500mg/kg (5500mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(3), Pg. 31, 1967. | |
mouse | LD50 | unreported | 8050mg/kg (8050mg/kg) | BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968. |
mouse | LDLo | subcutaneous | 2700mg/kg (2700mg/kg) | British Journal of Industrial Medicine. Vol. 1, Pg. 207, 1944. | |
rabbit | LD50 | skin | 9530uL/kg (9.53mL/kg) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 731, 1969. | |
rabbit | LD50 | unreported | 5017mg/kg (5017mg/kg) | BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968. |
rabbit | LDLo | intramuscular | 5500mg/kg (5500mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931. |
rabbit | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 502, 1966. | |
rabbit | LDLo | intravenous | 5gm/kg (5000mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931. |
rat | LC | inhalation | > 200mg/m3/4H (200mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981. | |
rat | LD50 | intraperitoneal | 5010mg/kg (5010mg/kg) | Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981. | |
rat | LD50 | intravenous | 3260mg/kg (3260mg/kg) | Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981. | |
rat | LD50 | oral | 4700mg/kg (4700mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(6), Pg. 28, 1982. | |
rat | LD50 | subcutaneous | 2800mg/kg (2800mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 49, 1974. | |
rat | LD50 | unreported | 13gm/kg (13000mg/kg) | BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968. |
rat | LDLo | intramuscular | 3300mg/kg (3300mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -1.30E+01 | deg C | EXP | |
Boiling Point | 197.3 | deg C | EXP | |
pKa Dissociation Constant | 15.1 | (none) | EXP | |
log P (octanol-water) | -1.36E+00 | (none) | EXP | |
Water Solubility | 1.00E+06 | mg/L | EXP | |
Vapor Pressure | 0.092 | mm Hg | 25 | EXP |
Henry's Law Constant | 6.00E-08 | atm-m3/mole | 25 | EXP |
Atmospheric OH Rate Constant | 7.70E-12 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.