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Substance Name: Ethylene glycol
RN: 107-21-1
UNII: FC72KVT52F
InChIKey: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Note

  • A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.

Molecular Formula

  • C2-H6-O2

Molecular Weight

  • 62.0674
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data
  • Unspecified / Unclassified Pesticide

Superlist Classification Codes

  • Ceiling 100 mg/m3 aerosol only; Not classifiable as a human carcinogen
  • Reportable Quantity (RQ) = 5000 lb

Names and Synonyms

Name of Substance

  • 1,2-Ethanediol
  • Ethylene glycol
  • Glycol

MeSH Heading

  • Ethylene glycol

Synonyms

  • 1,2-Dihydroxyethane
  • 1,2-Ethanediol
  • 146AR
  • 2-Hydroxyethanol
  • Aethylenglykol
  • Aethylenglykol [German]
  • AI3-03050
  • Caswell No. 441
  • CCRIS 3744
  • Dowtherm SR 1
  • EC 203-473-3
  • EINECS 203-473-3
  • EPA Pesticide Chemical Code 042203
  • Ethylene alcohol
  • Ethylene dihydrate
  • Ethylene glycol
  • Fridex
  • Glycol
  • Glycol alcohol
  • Glycol, ethylene-
  • HSDB 5012
  • Lutrol-9
  • Macrogol 400 BPC
  • Monoethylene glycol
  • NCI-C00920
  • Norkool
  • NSC 93876
  • Ramp
  • Tescol
  • Ucar 17
  • UNII-FC72KVT52F
  • Union Carbide XL 54 Type I De-icing Fluid
  • Zerex

Systematic Names

  • 1,2-Ethanediol
  • Ethane-1,2-diol
  • Ethylene glycol

Superlist Names

  • 1,2-Ethanediol
  • Ethylene glycol
  • Glycol

Registry Numbers

CAS Registry Number

  • 107-21-1

FDA UNII

  • FC72KVT52F

Other Registry Numbers

  • 1371582-33-0
  • 2088100-90-5
  • 37221-95-7
  • 71767-64-1

System Generated Number

  • 0000107211

Structure Descriptors

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChIKey

LYCAIKOWRPUZTN-UHFFFAOYSA-N

Smiles

C(CO)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 1650mg/kg (1650mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
cat LDLo subcutaneous 2gm/kg (2000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: OTHER CHANGES		 Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
child TDLo oral 5500mg/kg (5500mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Postgraduate Medical Journal. Vol. 52, Pg. 598, 1976.
dog LD50 oral 5500mg/kg (5500mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
guinea pig LD50 oral 6610mg/kg (6610mg/kg) GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig LD50 unreported 11150mg/kg (11150mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
guinea pig LDLo subcutaneous 5gm/kg (5000mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 51, Pg. 398, 1935.
human LDLo oral 398mg/kg (398mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: HEADACHE

LIVER: OTHER CHANGES		 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. Vol. 26(2), Pg. 48, 1983.
human LDLo oral 786mg/kg (786mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 373, 1976.
human TCLo inhalation 10000mg/m3 (10000mg/m3) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: COUGH		 Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
man LDLo unreported 1637mg/kg (1637mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 1195mg/kg (1195mg/kg) KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED

PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE		 Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991.
man TDLo oral 15gm/kg (15000mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED		 Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991.
man TDLo oral 16gm/kg (16000mg/kg) BEHAVIORAL: COMA

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED		 Human & Experimental Toxicology. Vol. 9, Pg. 317, 1990.
man TDLo oral 24gm/kg (24000mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 445, 2000.
mouse LC inhalation > 200mg/m3/2H (200mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981.
mouse LD50 intraperitoneal 5614mg/kg (5614mg/kg) BLOOD: CHANGES IN SPLEEN

KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA		 Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse LD50 intravenous 3gm/kg (3000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.
mouse LD50 oral 5500mg/kg (5500mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(3), Pg. 31, 1967.
mouse LD50 unreported 8050mg/kg (8050mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
mouse LDLo subcutaneous 2700mg/kg (2700mg/kg)   British Journal of Industrial Medicine. Vol. 1, Pg. 207, 1944.
rabbit LD50 skin 9530uL/kg (9.53mL/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 731, 1969.
rabbit LD50 unreported 5017mg/kg (5017mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
rabbit LDLo intramuscular 5500mg/kg (5500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA		 Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.
rabbit LDLo intraperitoneal 1gm/kg (1000mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 502, 1966.
rabbit LDLo intravenous 5gm/kg (5000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR		 Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.
rat LC inhalation > 200mg/m3/4H (200mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981.
rat LD50 intraperitoneal 5010mg/kg (5010mg/kg)   Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981.
rat LD50 intravenous 3260mg/kg (3260mg/kg)   Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981.
rat LD50 oral 4700mg/kg (4700mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(6), Pg. 28, 1982.
rat LD50 subcutaneous 2800mg/kg (2800mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 49, 1974.
rat LD50 unreported 13gm/kg (13000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: EXCITEMENT		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
rat LDLo intramuscular 3300mg/kg (3300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.30E+01 deg C   EXP
Boiling Point 197.3 deg C   EXP
pKa Dissociation Constant 15.1 (none)   EXP
log P (octanol-water) -1.36E+00 (none)   EXP
Water Solubility 1.00E+06 mg/L   EXP
Vapor Pressure 0.092 mm Hg 25 EXP
Henry's Law Constant 6.00E-08 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 7.70E-12 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.