Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Sarin
RN: 107-44-8
UNII: B4XG72QGFM
InChIKey: DYAHQFWOVKZOOW-UHFFFAOYSA-N

Notes

  • An organophosphorus ester compound that produces potent and irreversible inhibition of cholinesterase. It is toxic to the nervous system and is a chemical warfare agent.
  • Chemical Weapons Convention Schedule 1

Molecular Formula

  • C4-H10-F-O2-P

Molecular Weight

  • 140.093
 

Classification Codes

Classification Codes

  • Chemical Warfare Agents
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Neurotransmitter Agents
  • Noxae
  • Poisons

Superlist Classification Code

  • Threshold Planning Quantity (TPQ) = 10 lb

Names and Synonyms

Name of Substance

  • Sarin

MeSH Heading

  • Sarin

Synonyms

  • (+-)-Isopropyl methylphosphonofluoridate
  • 1-Methylethyl (+-)-methylphosphonofluoridate
  • 4-04-00-03507 (Beilstein Handbook Reference)
  • BRN 1750114
  • CCRIS 3416
  • EA 1208
  • GB
  • HSDB 6382
  • IMPF
  • Isopropoxymethylphoshoryl fluoride
  • Isopropoxymethylphosphoryl fluoride
  • Isopropyl methanefluorophosphonate
  • Isopropyl methylfluorophosphate
  • Isopropyl-methyl-phosphoryl fluoride
  • Isopropylester kyseliny methylfluorfosfonove
  • Isopropylester kyseliny methylfluorfosfonove [Czech]
  • Methlyfluorophosphonic acid isopropyl ester
  • Methylfluorphosphorsaeureisopropylester
  • Methylfluorphosphorsaeureisopropylester [German]
  • Methylphosphonofluoride acid, isopropyl ester
  • Methylphosphonofluoridic acid 1-methylethyl ester
  • Methylphosphonofluoridic acid isopropyl ester
  • MFI
  • Nerve agent
  • o-Isopropyl methylphosphonofluoridate
  • Phosphine oxide, fluoroisopropoxymethyl-
  • Phosphonofluoridic acid, methyl-, 1-methylethyl ester
  • Phosphonofluoridic acid, methyl-, isopropyl ester, (+-)-
  • Phosphoric acid, methylfluoro-, isopropyl ester
  • Sarin
  • Sarin II
  • T-144
  • T-2106
  • TL 1618
  • Trilone 46
  • UNII-B4XG72QGFM

Systematic Names

  • Phosphonofluoridic acid, methyl-, 1-methylethyl ester
  • Phosphonofluoridic acid, methyl-, isopropyl ester
  • Phosphonofluoridic acid, P-methyl-, 1-methylethyl ester
  • Sarin

Superlist Name

  • Sarin

Registry Numbers

CAS Registry Number

  • 107-44-8

FDA UNII

  • B4XG72QGFM

Other Registry Numbers

  • 102490-54-0
  • 50642-23-4

System Generated Number

  • 0000107448

Structure Descriptors

InChI

1S/C4H10FO2P/c1-4(2)7-8(3,5)6/h4H,1-3H3

InChIKey

DYAHQFWOVKZOOW-UHFFFAOYSA-N

Smiles

CC(C)OP(=O)(C)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 22ug/kg (0.022mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961.
cat LD50 subcutaneous 30ug/kg (0.03mg/kg)   Toxicology and Applied Pharmacology. Vol. 91, Pg. 55, 1987.
chicken LD50 subcutaneous 16673ug/kg (16.673mg/kg)   Archives of Toxicology. Vol. 52, Pg. 71, 1983.
dog LD50 intravenous 19ug/kg (0.019mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961.
guinea pig LC50 inhalation 128mg/m3/2M (128mg/m3)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1126, 1986.
guinea pig LD50 subcutaneous 30ug/kg (0.03mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
hamster LD50 subcutaneous 95ug/kg (0.095mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
human LD50 skin 28mg/kg (28mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Science Journal. Vol. 3(4), Pg. 33, 1967.
human TDLo oral 2ug/kg (0.002mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION
Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
man LDLo intramuscular 30ug/kg (0.03mg/kg)   Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
man TCLo inhalation 90ug/m3 (0.09mg/m3) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE Archives of Toxicology. Vol. 56, Pg. 201, 1985.
man TDLo oral 102ug/kg/3D-I (0.102mg/kg) BLOOD: OTHER CHANGES Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
monkey LD50 intramuscular 22300ng/kg (0.0223mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Fundamental and Applied Toxicology. Vol. 5, Pg. S169, 1985.
monkey LD50 intravenous 20ug/kg (0.02mg/kg)   Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
mouse LC50 inhalation 5mg/m3/30M (5mg/m3)   Deutsche Gesundheitswesen. Vol. 15, Pg. 2179, 1960.
mouse LD50 intramuscular 164ug/kg (0.164mg/kg)   Journal of Medicinal Chemistry. Vol. 31, Pg. 807, 1988.
mouse LD50 intraperitoneal 283ug/kg (0.283mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 172, Pg. 62, 1968.
mouse LD50 intravenous 109ug/kg (0.109mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: INCONTINENCE
Journal of Toxicology and Environmental Health. Vol. 26, Pg. 437, 1989.
mouse LD50 skin 1080ug/kg (1.08mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: COMA
National Technical Information Service. Vol. PB158-508,
mouse LD50 subcutaneous 60ug/kg (0.06mg/kg)   Deutsche Gesundheitswesen. Vol. 15, Pg. 2179, 1960.
pig LD50 intravenous 15ug/kg (0.015mg/kg)   Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
pig LD50 skin 116mg/kg (116mg/kg)   Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
rabbit LD50 intravenous 15ug/kg (0.015mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 353, 1961.
rabbit LD50 skin 925ug/kg (0.925mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
National Technical Information Service. Vol. PB158-508,
rabbit LD50 subcutaneous 30ug/kg (0.03mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 40, Pg. 109, 1977.
rat LD50 intramuscular 108ug/kg (0.108mg/kg)   Fundamental and Applied Toxicology. Vol. 5, Pg. S84, 1985.
rat LD50 intraperitoneal 218ug/kg (0.218mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 139, Pg. 390, 1963.
rat LD50 intravenous 39ug/kg (0.039mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 139, Pg. 390, 1963.
rat LD50 oral 550ug/kg (0.55mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
National Technical Information Service. Vol. PB158-508,
rat LD50 skin 2500ug/kg (2.5mg/kg)   Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
rat LD50 subcutaneous 103ug/kg (0.103mg/kg)   British Journal of Pharmacology. Vol. 39, Pg. 822, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -5.70E+01 deg C   EXP
Boiling Point 147 deg C   EXP
log P (octanol-water) 0.3 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 2.86 mm Hg 25 EXP
Henry's Law Constant 5.72E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.71E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.