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Substance Name: TEPP [BSI:ISO]
RN: 107-49-3
UNII: 28QKT80KX2
InChIKey: IDCBOTIENDVCBQ-UHFFFAOYSA-N

Note

  • Topical agent for glaucoma.

Molecular Formula

  • C8-H20-O7-P2

Molecular Weight

  • 290.187
 

Classification Codes

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Human Data
  • Insecticide
  • Out-Dated Pesticide

Superlist Classification Codes

  • Reportable Quantity (RQ) = 10 lb
  • Threshold Planning Quantity (TPQ) = 100 lb
  • TWA 0.05 mg/m3; skin
  • TWA 0.05 mg/m3; skin; BEI
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Names and Synonyms

Results Name

  • TEPP [BSI:ISO]

Name of Substance

  • Ethyl pyrophosphate [INN]
  • TEPP [BSI:ISO]
  • Tetraethyl pyrophosphate

Synonyms

  • 4-01-00-01342 (Beilstein Handbook Reference)
  • AI3-10622
  • Bis-O,O-diethylphosphoric anhydride
  • Bladan
  • Bladan (VAN)
  • BRN 1714017
  • Caswell No. 838
  • Diphosphoric acid tetraethyl ester
  • EA 1285
  • EINECS 203-495-3
  • ENT 18,771
  • EPA Pesticide Chemical Code 079601
  • Ethyl pyrophosphate
  • Ethyl pyrophosphate (Et4P2O7)
  • Ethyl pyrophosphate, tetra-
  • Fosvex
  • Grisol
  • HEPT
  • Hepthexamite
  • Hexamite
  • HSDB 842
  • Killax
  • Killex
  • Kilmite 40
  • Lethalaire G-52
  • Lirohex
  • Mortopal
  • Nifos
  • Nifos T
  • Nifost
  • NSC 14707
  • O,O,O,O-Tetraaethyl-diphosphat, bis(O,O-diaethylphosphorsaeure-anhydrid)
  • O,O,O,O-Tetraaethyl-diphosphat, bis(O,O-diaethylphosphorsaeure-anhydrid) [German]
  • O,O,O,O-Tetraethyl-difosfaat
  • O,O,O,O-Tetraethyl-difosfaat [Dutch]
  • O,O,O,O-Tetraetil-pirofosfato
  • O,O,O,O-Tetraetil-pirofosfato [Italian]
  • Pyrophosphate de tetraethyle
  • Pyrophosphate de tetraethyle [French]
  • RCRA waste number P111
  • TEPP
  • Tetraaethylpyrophosphorsaeureester
  • Tetraaethylpyrophosphorsaeureester [German]
  • Tetraethyl diphosphate
  • Tetraethyl pyrofosfaat
  • Tetraethyl pyrofosfaat [Belgian]
  • Tetraethyl pyrofosfaat [Dutch]
  • Tetraethyl pyrophosphate
  • Tetraethyldifosfat
  • Tetraethyldifosfat [Czech]
  • Tetraethylpyrofosfat
  • Tetraethylpyrofosfat [Czech]
  • Tetraethylpyrophosphate
  • Tetraethylpyrophosphorsaeureester
  • Tetraethylpyrophosphorsaeureester [German]
  • Tetrastigmine
  • Tetron
  • Tetron-100
  • UNII-28QKT80KX2
  • Vapotone

Systematic Names

  • Diphosphoric acid, tetraethyl ester
  • Pyrophosphoric acid, tetraethyl ester
  • TEPP

Superlist Names

  • Diphosphoric acid, tetraethyl ester
  • NA2783
  • NA3018
  • RCRA waste no. P111
  • TEPP
  • Tetraethyl pyrophosphate
  • Tetraethyl pyrophosphate, liquid
  • Tetraethyl pyrophosphate, liquid [NA3018] [Poison]
  • Tetraethyl pyrophosphate, solid
  • Tetraethyl pyrophosphate, solid [NA2783] [Poison]

Registry Numbers

CAS Registry Number

  • 107-49-3

FDA UNII

  • 28QKT80KX2

System Generated Number

  • 0000107493

Structure Descriptors

InChI

1S/C8H20O7P2/c1-5-11-16(9,12-6-2)15-17(10,13-7-3)14-8-4/h5-8H2,1-4H3

InChIKey

IDCBOTIENDVCBQ-UHFFFAOYSA-N

Smiles

O(P(OCC)(OCC)=O)P(OCC)(OCC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 1300ug/kg (1.3mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
duck LD50 oral 3560ug/kg (3.56mg/kg)   Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979.
duck LD50 skin 64mg/kg (64mg/kg)   Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979.
frog LD50 parenteral 34mg/kg (34mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 124, Pg. 212, 1960.
guinea pig LD50 oral 2300ug/kg (2.3mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 156, 1952.
guinea pig LD50 subcutaneous 700ug/kg (0.7mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 14, Pg. 5, 1959.
human LDLo intramuscular 286ug/kg (0.286mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING
"Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.
human LDLo oral 1429ug/kg (1.429mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: EXCITEMENT

PERIPHERAL NERVE AND SENSATION: PARESTHESIS
"Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.
human TDLo oral 309ug/kg (0.309mg/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: OTHER CHANGES
"Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.
human TDLo parenteral 71ug/kg (0.071mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
"Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.
man LDLo intramuscular 380ug/kg (0.38mg/kg)   Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
man LDLo oral 1700ug/kg (1.7mg/kg)   Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
mouse LD50 intraperitoneal 830ug/kg (0.83mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 121, Pg. 104, 1959.
mouse LD50 intravenous 200ug/kg (0.2mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 9, Pg. 299, 1954.
mouse LD50 oral 3mg/kg (3mg/kg)   Agricultural and Biological Chemistry. Vol. 27, Pg. 684, 1963.
mouse LD50 skin 8mg/kg (8mg/kg)   Agricultural and Biological Chemistry. Vol. 27, Pg. 684, 1963.
mouse LD50 subcutaneous 500ug/kg (0.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 875, 1979.
pigeon LD50 intravenous 180ug/kg (0.18mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 102, Pg. 371, 1955.
rabbit LD50 subcutaneous 2mg/kg (2mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
rabbit LD50 unreported 1mg/kg (1mg/kg)   American Journal of Ophthalmology. Vol. 53, Pg. 512, 1962.
rabbit LDLo intravenous 300ug/kg (0.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
British Journal of Pharmacology and Chemotherapy. Vol. 8, Pg. 466, 1953.
rabbit LDLo skin 17uL/kg (0.017mL/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: EXCITEMENT
National Technical Information Service. Vol. OTS0534856,
rat LD50 intramuscular 1800ug/kg (1.8mg/kg)   Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
rat LD50 intraperitoneal 650ug/kg (0.65mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 353, 1947.
rat LD50 intravenous 300ug/kg (0.3mg/kg)   Canadian Journal of Biochemistry and Physiology. Vol. 34, Pg. 197, 1956.
rat LD50 oral 500ug/kg (0.5mg/kg)   Pharmaceutical Journal. Vol. 185, Pg. 361, 1960.
rat LD50 skin 2400ug/kg (2.4mg/kg)   Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.
rat LD50 subcutaneous 279ug/kg (0.279mg/kg)   Fundamental and Applied Toxicology. Vol. 4, Pg. S195, 1984.
rat LD50 unreported 1120ug/kg (1.12mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 379, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.450 (none)   EST
Water Solubility 1.00E+06 mg/L   EXP
Henry's Law Constant 1.00E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.73E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.