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Substance Name: 1-Methoxy-2-hydroxypropane
RN: 107-98-2
UNII: 74Z7JO8V3U
InChIKey: ARXJGSRGQADJSQ-UHFFFAOYSA-N

Molecular Formula

  • C4-H10-O2

Molecular Weight

  • 90.121
 

Classification Codes

Classification Codes

  • Human Data
  • Reproductive Effect
  • Skin / Eye Irritant

Superlist Classification Code

  • TWA (100 ppm); STEL (150 ppm)
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Names and Synonyms

Name of Substance

  • 1-Methoxy-2-hydroxypropane
  • 1-Methoxy-2-propanol
  • 2-Propanol, 1-methoxy-
  • Methoxyisopropanol
  • Propylene glycol methyl ether

Synonyms

  • 1-Methoxy-2-hydroxypropane
  • 1-Methoxy-2-propanol
  • 2-Methoxy-1-methylethanol
  • 2-Propanol, 1-methoxy-
  • 3-01-00-02146 (Beilstein Handbook Reference)
  • AI3-15573
  • BRN 1731270
  • Closol
  • Dowanol 33B
  • Dowtherm 209
  • EC 203-539-1
  • EINECS 203-539-1
  • HSDB 1016
  • Methyl proxitol
  • NSC 2409
  • PGME
  • Poly-Solve MPM
  • Propasol solvent M
  • Propylene glycol 1-methyl ether
  • Ucar Solvent LM (Obs.)
  • UNII-74Z7JO8V3U

Systematic Names

  • 1-Methoxypropan-2-ol
  • 2-Propanol, 1-methoxy-

Superlist Names

  • 1-Methoxy-2-propanol [UN3092] [Flammable liquid]
  • 2-Methoxy-1-methylethanol
  • 2-Propanol, 1-methoxy-
  • Propylene glycol methyl ether
  • Propylene glycol monomethyl ether
  • UN3092

Registry Numbers

CAS Registry Number

  • 107-98-2

FDA UNII

  • 74Z7JO8V3U

Other Registry Number

  • 58769-19-0

System Generated Number

  • 0000107982

Structure Descriptors

InChI

1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3

InChIKey

ARXJGSRGQADJSQ-UHFFFAOYSA-N

Smiles

C([C@@H](C)O)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
dog LD50 oral 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
guinea pig LCLo inhalation 15000ppm/7H (15000ppm) BEHAVIORAL: SLEEP AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 509, 1954.
human TCLo inhalation 3000ppm (3000ppm) GASTROINTESTINAL: NAUSEA OR VOMITING

SENSE ORGANS AND SPECIAL SENSES: TUMORS: OLFACTION

BEHAVIORAL: GENERAL ANESTHETIC
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.
mouse LD intraperitoneal > 500mg/kg (500mg/kg)   "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 4, Pg. 110, 1952.
mouse LD50 intravenous 5300mg/kg (5300mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
mouse LD50 oral 11700mg/kg (11700mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rabbit LCLo inhalation 15000ppm/7H (15000ppm)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 509, 1954.
rabbit LD50 intravenous 1200mg/kg (1200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rabbit LD50 oral 5700mg/kg (5700mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rabbit LD50 skin 13gm/kg (13000mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.
rabbit LD50 subcutaneous 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rat LC50 inhalation 10000ppm/5H (10000ppm)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.
rat LD50 intraperitoneal 3720mg/kg (3720mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3977, 1982.
rat LD50 intravenous 4200mg/kg (4200mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rat LD50 subcutaneous 7800mg/kg (7800mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rat LDLo oral 3739mg/kg (3739mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0520402,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.42E+02 deg C   EXP
Boiling Point 119 deg C   EXP
log P (octanol-water) -0.490 (none)   EST
Water Solubility 1.00E+06 mg/L   EXP
Vapor Pressure 12.5 mm Hg 25 EXP
Henry's Law Constant 9.20E-07 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.86E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.