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Substance Name: Granisetron hydrochloride [USAN:USP]
RN: 107007-99-8
UNII: 318F6L70J8
InChIKey: QYZRTBKYBJRGJB-WQTKJZBYSA-N

Note

  • A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

Molecular Formula

  • C18-H24-N4-O.Cl-H

Molecular Weight

  • 348.8755
 

Classification Codes

  • Anti-Emetic
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Granisetron hydrochloride [USAN:USP]

Synonyms

  • 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide monohydrochloride
  • BRL 43694A
  • endo-1-Methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide hydrochloride
  • Granisetron HCl
  • Granisetron hydrochloride
  • Granisetron hydrochloride preservative free
  • Granisol
  • Kytril
  • Kytril Injection
  • UNII-318F6L70J8

Systematic Name

  • 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, monohydrochloride, endo-

Registry Numbers

CAS Registry Number

  • 107007-99-8

FDA UNII

  • 318F6L70J8

Related Registry Number

  • 109889-09-0 (Parent)

System Generated Number

  • 0107007998

Molecular Formulas

Molecular Formula

  • C18-H24-N4-O.Cl-H

Molecular Formula Fragments

  • C18-H24-N4-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

InChIKey

QYZRTBKYBJRGJB-WQTKJZBYSA-N

Smiles

Cl.CN1[C@@H]2CCC[C@H]1CC(C2)NC(=O)c3nn(C)c4ccccc34

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3mg/kg (3mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
Yakkyoku. Pharmacy. Vol. 43, Pg. 589, 1992.
dog LDLo oral 15mg/kg (15mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: TREMOR
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 2697, 1995.
mouse LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990.
mouse LD50 oral 350mg/kg (350mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
rat LD50 intravenous 14mg/kg (14mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990.
rat LD50 oral 350mg/kg (350mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.