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Substance Name: Loxiglumide [INN]
RN: 107097-80-3
UNII: 77MPX3N42I
InChIKey: QNQZBKQEIFTHFZ-UHFFFAOYSA-N

Note

  • Cholecystokinin receptor antagonist.

Molecular Formula

  • C21-H30-Cl2-N2-O5

Molecular Weight

  • 461.383
 

Classification Codes

  • Drug / Therapeutic Agent
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms

Name of Substance

  • Loxiglumide
  • Loxiglumide [INN]

Synonyms

  • (+-)-4-((3,4-Dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5-oxopentanoic acid
  • CCRIS 8590
  • CR 1505
  • D,L-4-(3,4-Dichlorobenzoylamino)-5-(N-3-methoxypropylpentylamino)-5-oxo-pentanoic acid
  • Loxiglumida
  • Loxiglumida [Spanish]
  • Loxiglumide
  • Loxiglumidum
  • Loxiglumidum [Latin]
  • UNII-77MPX3N42I

Systematic Names

  • (+-)-4-(3,4-Dichlorobenzamido)-N-(3-methoxypropyl)-N-pentylglutaramic acid
  • Pentanoic acid, 4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5-oxo-, (+-)-

Registry Numbers

CAS Registry Number

  • 107097-80-3

FDA UNII

  • 77MPX3N42I

System Generated Number

  • 0107097803

Structure Descriptors

InChI

1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)

InChIKey

QNQZBKQEIFTHFZ-UHFFFAOYSA-N

Smiles

C([C@@H](NC(c1cc(c(Cl)cc1)Cl)=O)CCC(O)=O)(N(CCCCC)CCCOC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 450mg/kg (450mg/kg)   Journal of Surgical Oncology. Vol. 53, Pg. 47, 1993.
mouse LD50 intravenous 396mg/kg (396mg/kg)   United States Patent Document. Vol. #4769389,
mouse LD50 oral 460mg/kg (460mg/kg)   Journal of Surgical Oncology. Vol. 53, Pg. 47, 1993.
mouse LD50 subcutaneous 500mg/kg (500mg/kg)   Journal of Surgical Oncology. Vol. 53, Pg. 47, 1993.