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Substance Name: AT-406
RN: 1071992-99-8


  • Inhibits inhibitor of apoptosis proteins; in phase I clinical trials (2011) as an antineoplastic agent.
  • Inhibits inhibitor of apoptosis proteins; in phase I clinical trials (2011) as an antineoplastic agent

    NCI: An orally bioavailable inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins with potential apoptotic inducing and antineoplastic activity. IAP inhibitor AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP). This may restore and promote the induction of apoptosis through apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains. (NCI Thesaurus)

Molecular Formula

  • C32-H43-N5-O4

Molecular Weight

  • 561.7227
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Names and Synonyms

Name of Substance

  • AT-406


  • AT 406
  • AT406
  • D 1143
  • Debio 1143
  • N65WC8PXDD
  • SM 406

Systematic Name

  • (5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-(((2S)-2-(methylamino)-1-oxopropyl)amino)-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo(1,2-a)(1,5)diazocine-8-carboxamide

Registry Numbers

CAS Registry Number

  • 1071992-99-8

System Generated Number

  • 1071992998

Structure Descriptors