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Substance Name: Binimetinib [USAN:INN]
RN: 606143-89-9
UNII: 181R97MR71
InChIKey: ACWZRVQXLIRSDF-UHFFFAOYSA-N

Note

  • NCI: binimetinib An orally available inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2) with potential antineoplastic activity. Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types. (NCI Thesaurus)

Molecular Formulas

  • C17-H15-Br-F2-N4-O3
  • Unspecified

Molecular Weight

  • 441.2305
 
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Names and Synonyms

Name of Substance

  • Binimetinib [USAN:INN]
  • MEK-162

Synonyms

  • ARRY 162
  • ARRY-438162
  • Binimetinib
  • MEK162
  • UNII-181R97MR71

Systematic Name

  • ARRY 438162

Registry Numbers

CAS Registry Number

  • 606143-89-9

FDA UNII

  • 181R97MR71

Other Registry Numbers

  • 1073666-70-2
  • 1201685-05-3
  • 1417448-81-7

System Generated Number

  • 0606143899

Structure Descriptors

InChI

1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChIKey

ACWZRVQXLIRSDF-UHFFFAOYSA-N

Smiles

Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(cc12)C(=O)NOCCO