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Substance Name: Polaprezinc [INN]
RN: 107667-60-7
UNII: 0WA1B15A1Z
InChIKey: IGXZLYMCFZHNKW-FJXQXJEOSA-L

Note

  • Stimulates bone growth.

Molecular Formula

  • (C9-H12-N4-O3-Zn)mult-

Molecular Weight

  • 289.6088
 

Classification Codes

  • Anti-Ulcer Agents
  • Gastrointestinal Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Polaprezinc
  • Polaprezinc [INN]

Synonyms

  • beta-Alanyl-L-histidinato zinc
  • Carnosine zinc
  • catena-Poly(zinc-mu-(beta-alanyl-L-histidinato(2-)-N,N(sup N),O:N(sup tau)))
  • CCRIS 3974
  • N(alpha)-(3-Aminopropionyl)histidinato(2-)N1,N2,O(alpha))-zinc
  • Polaprezinc
  • Promac
  • Promac (antiulcer agent)
  • UNII-0WA1B15A1Z
  • Z 103
  • Zinc L-carnosine
  • Zinc N-(3-aminopropionyl)histidine

Systematic Names

  • catena-Poly(zinc-mu-(beta-alanyl-L-histidinato(2(-))-N,N(sup N),O:N(sup tau)))
  • Z 103
  • Zinc, (beta-alanyl-kappaN-L-histidinato(2-)-kappaN,kappaO)-
  • Zinc, (N-beta-alanyl-L-histidinato(2-)-N,N(N),N3,O(alpha))-, (T-4)-
  • Zinc, (N-beta-alanyl-L-histidinato(2-)-N,N(sup N),O(sup alpha))-

Registry Numbers

CAS Registry Number

  • 107667-60-7

FDA UNII

  • 0WA1B15A1Z

Other Registry Numbers

  • 120520-26-5
  • 132613-07-1

System Generated Number

  • 0107667607

Molecular Formulas

Molecular Formula

  • (C9-H12-N4-O3-Zn)mult-

Molecular Formula Fragments

  • C9-H12-N4-O3-Zn
  • COMPONENT

Structure Descriptors

InChI

1S/C9H14N4O3.Zn/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6;/h4-5,7H,1-3,10H2,(H3,11,12,13,14,15,16);/q;+2/p-2/t7-;/m0./s1

InChIKey

IGXZLYMCFZHNKW-FJXQXJEOSA-L

Smiles

C(CC(=O)[NH-][C@@H](Cc1cnc[nH]1)C(=O)[O-])N[Zn+2]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 45, Pg. 52, 1995.
monkey LD oral > 626mg/kg (626mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 562, 1993.
mouse LD50 intraperitoneal 165mg/kg (165mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1033, 1991.
mouse LD50 intraperitoneal 165mg/kg (165mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1033, 1991.
mouse LD50 oral 1269mg/kg (1269mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1033, 1991.
mouse LD50 subcutaneous 758mg/kg (758mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1033, 1991.
rat LD50 intraperitoneal 405mg/kg (405mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1033, 1991.
rat LD50 oral 7375mg/kg (7375mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1033, 1991.
rat LD50 oral 7375mg/kg (7375mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1033, 1991.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1033, 1991.