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Substance Name: Eplerenone [USAN:INN:BAN]
RN: 107724-20-9
UNII: 6995V82D0B
InChIKey: JUKPWJGBANNWMW-VWBFHTRKSA-N

Notes

  • A selective aldosterone receptor antagonist.
  • A selective aldosterone receptor antagonist; exists in equilibrium with the ring open form SC70303.

Molecular Formula

  • C24-H30-O6

Molecular Weight

  • 414.495
 

Classification Codes

  • Aldosterone Antagonist
  • Aldosterone Antagonists
  • Antihypertensive
  • Diuretics
  • Diuretics, Potassium Sparing
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Mineralocorticoid Receptor Antagonists
  • Natriuretic Agents

Names and Synonyms

Name of Substance

  • Eplerenone
  • Eplerenone [USAN:INN:BAN]
  • Epoxymexrenone

Synonyms

  • (+)-Eplerenone
  • 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester
  • CGP 30083
  • CGP-30083
  • Eplerenone
  • Epoxymexrenone
  • HSDB 7522
  • Inspra
  • SC 6110
  • SC-66110
  • Selara
  • UNII-6995V82D0B

Systematic Name

  • Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-

Registry Numbers

CAS Registry Number

  • 107724-20-9

FDA UNII

  • 6995V82D0B

System Generated Number

  • 0107724209

Structure Descriptors

InChI

1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChIKey

JUKPWJGBANNWMW-VWBFHTRKSA-N

Smiles

C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC