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Substance Name: Cyclohexylamine
RN: 108-91-8
UNII: I6GH4W7AEG
InChIKey: PAFZNILMFXTMIY-UHFFFAOYSA-N

Note

  • A family of alicyclic hydrocarbons containing an amine group with the general formula R-C6H10NH2.

Molecular Formula

  • C6-H13-N

Molecular Weight

  • 99.1757
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Insecticide
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Threshold Planning Quantity (TPQ) = 10000 lb
  • TWA (10 ppm); Not classifiable as a human carcinogen

Names and Synonyms

Name of Substance

  • Cyclohexylamine

MeSH Heading

  • Cyclohexylamines

Synonyms

  • 1-Aminocyclohexane
  • 1-Cyclohexylamine
  • 4-12-00-00008 (Beilstein Handbook Reference)
  • AI3-15323
  • Aminocyclohexane
  • Aminohexahydrobenzene
  • Aniline, hexahydro-
  • Benzenamine, hexahydro-
  • BRN 0471175
  • CCRIS 3645
  • CHA
  • Cyclohexanamine
  • Cyclohexylamine
  • EC 203-629-0
  • EINECS 203-629-0
  • Hexahydroaniline
  • Hexahydrobenzenamine
  • HSDB 918
  • UNII-I6GH4W7AEG

Systematic Names

  • Cyclohexanamine
  • Cyclohexylamine

Superlist Names

  • Cyclohexanamine
  • Cyclohexylamine
  • Cyclohexylamine [UN2357] [Corrosive]
  • UN2357

Registry Numbers

CAS Registry Number

  • 108-91-8

FDA UNII

  • I6GH4W7AEG

Other Registry Numbers

  • 1357848-57-7
  • 143247-75-0
  • 1533423-50-5
  • 157973-60-9

System Generated Number

  • 0000108918

Structure Descriptors

InChI

1S/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2

InChIKey

PAFZNILMFXTMIY-UHFFFAOYSA-N

Smiles

C1(CCCCC1)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 53S, 1969.
guinea pig LCLo inhalation 1200ppm/7H (1200ppm) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Industrial Medicine and Surgery. Vol. 19, Pg. 317, 1950.
mammal (species unspecified) LD50 intraperitoneal 200mg/kg (200mg/kg) VASCULAR: SHOCK

BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

LIVER: OTHER CHANGES
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 311, 1952.
mouse LC50 inhalation 1070mg/m3 (1070mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(11), Pg. 51, 1963.
mouse LD50 intraperitoneal 129mg/kg (129mg/kg)   Pharmaceutical Chemistry Journal Vol. 22, Pg. 469, 1988.
mouse LD50 intravenous 200mg/kg (200mg/kg)   International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
mouse LD50 oral 224mg/kg (224mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 41, 1982.
mouse LD50 subcutaneous 1150mg/kg (1150mg/kg)   Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 4, Pg. 659, 1958.
mouse LD50 unreported 770mg/kg (770mg/kg)   Toxicology and Applied Pharmacology. Vol. 14, Pg. 654, 1969.
rabbit LCLo inhalation 150ppm/7H (150ppm)   Industrial Medicine and Surgery. Vol. 19, Pg. 317, 1950.
rabbit LD50 skin 320uL/kg (0.32mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rabbit LDLo parenteral 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Industrial and Engineering Chemistry. Vol. 29, Pg. 1247, 1937.
rat LC50 inhalation 7500mg/m3 (7500mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(11), Pg. 51, 1963.
rat LD50 intraperitoneal 300mg/kg (300mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 53S, 1969.
rat LD50 oral 11mg/kg (11mg/kg) LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: OTHER CHANGES
National Technical Information Service. Vol. OTS0534836,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.77E+01 deg C   EXP
Boiling Point 134 deg C   EXP
pKa Dissociation Constant 10.63 (none) 23 EXP
log P (octanol-water) 1.49 (none)   EXP
Water Solubility 1.00E+06 mg/L 20 EXP
Vapor Pressure 10.1 mm Hg 25 EXP
Henry's Law Constant 4.16E-06 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 5.54E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.