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Substance Name: Meticrane [INN:DCF:JAN]
RN: 1084-65-7
UNII: I7EKN1924Q
InChIKey: FNQQBFNIYODEMB-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C10-H13-N-O4-S2

Molecular Weight

  • 275.348
 
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Names and Synonyms

Name of Substance

  • Meticrane [INN:DCF:JAN]

Synonyms

  • 6-Methyl-3,4-dihydro-2H-1-benzothiopyran-7-sulfonamide 1,1-dioxide
  • 6-Methyl-7-sulfamido-thiochroman-1,1-dioxide
  • 6-Methylthiochroman-7-sulfonamide 1,1-dioxide
  • Arresten
  • E-103-E
  • EINECS 214-112-4
  • Fontiliz
  • Meticrane
  • Meticrano
  • Meticrano [INN-Spanish]
  • Meticranum
  • Meticranum [INN-Latin]
  • SD 17102
  • UNII-I7EKN1924Q

Systematic Names

  • 2H-1-Benzothiopyran-7-sulfonamide, 3,4-dihydro-6-methyl-, 1,1-dioxide (9CI)
  • 6-Methylthiochroman-7-sulfonamide 1,1-dioxide
  • Meticrane
  • Thiochroman-7-sulfonamide, 6-methyl-, 1,1-dioxide

Registry Numbers

CAS Registry Number

  • 1084-65-7

FDA UNII

  • I7EKN1924Q

System Generated Number

  • 0001084657

Structure Descriptors

InChI

1S/C10H13NO4S2/c1-7-5-8-3-2-4-16(12,13)10(8)6-9(7)17(11,14)15/h5-6H,2-4H2,1H3,(H2,11,14,15)

InChIKey

FNQQBFNIYODEMB-UHFFFAOYSA-N

Smiles

c12S(=O)(=O)CCCc1cc(C)c(S(N)(=O)=O)c2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 10gm/kg (10000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 217, 1974.
mouse LD50 intravenous 325mg/kg (325mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 217, 1974.
mouse LD50 oral > 20gm/kg (20000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3560, 1973.
mouse LD50 subcutaneous > 20gm/kg (20000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3560, 1973.
rat LD50 intravenous 445mg/kg (445mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 217, 1974.
rat LD50 oral > 16gm/kg (16000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3560, 1973.
rat LD50 subcutaneous > 15gm/kg (15000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3560, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 236.5 deg C   EXP
log P (octanol-water) 1.260 (none)   EST
Atmospheric OH Rate Constant 1.22E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.