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Substance Name: Nordazepam [INN]
RN: 1088-11-5
UNII: 67220MCM01
InChIKey: AKPLHCDWDRPJGD-UHFFFAOYSA-N

Note

  • An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.

Molecular Formula

  • C15-H11-Cl-N2-O

Molecular Weight

  • 270.7179
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Mutation Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Nordazepam
  • Nordazepam [INN]

MeSH Heading

  • Nordazepam

Synonyms

  • 1-Demethyldiazepam
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-
  • 5-24-04-00291 (Beilstein Handbook Reference)
  • 7-Chlor-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-on
  • 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
  • A 101
  • A101
  • BRN 0751823
  • Calmday
  • CCRIS 9181
  • Chlordesmethyldiazepam
  • Dealkylprazepam
  • Demadar
  • Desalkylprazepam
  • Desmethyldiazepam
  • DMDZ
  • EINECS 214-123-4
  • Lomax
  • Madar
  • N-Demethyldiazepam
  • N-Deoxydemoxapam
  • N-Deoxydemoxepam
  • N-Descyclopropylmethylprazepam
  • N-Desmethyldiazepam
  • N1-Desmethyldiazepam
  • NDD
  • NDZ
  • Nordazepam
  • Nordazepamum
  • Nordazepamum [INN-Latin]
  • Nordiazepam
  • Norprazepam
  • NSC 46078
  • Ro 5-2180
  • Sopax
  • Stilny
  • UNII-67220MCM01
  • Vegesan

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
  • 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
  • Nordazepam

Superlist Names

  • DEA No. 2838
  • Nordiazepam

Registry Numbers

CAS Registry Number

  • 1088-11-5

FDA UNII

  • 67220MCM01

System Generated Number

  • 0001088115

Structure Descriptors

InChI

InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)

InChIKey

AKPLHCDWDRPJGD-UHFFFAOYSA-N

Smiles

Clc1ccc2NC(=O)CN=C(c3ccccc3)c2c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
mouse LD50 intraperitoneal 290mg/kg (290mg/kg) BEHAVIORAL: ANTICONVULSANT European Journal of Pharmacology. Vol. 16, Pg. 311, 1971.
mouse LD50 oral 670mg/kg (670mg/kg) BEHAVIORAL: ANTICONVULSANT European Journal of Pharmacology. Vol. 4, Pg. 467, 1968.
rat LD intraperitoneal > 2gm/kg (2000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD oral > 4gm/kg (4000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD oral > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 216.5 deg C   EXP
log P (octanol-water) 2.93 (none)   EXP
Water Solubility 57 mg/L 25 EST
Vapor Pressure 6.44E-09 mm Hg 25 EST
Henry's Law Constant 1.78E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.35E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.