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Substance Name: 3-Carbamyl-(3'-picolyl)-4-methoxy-1-benzamide
RN: 108828-56-4
InChIKey: QWZWECXMQXZQOG-UHFFFAOYSA-N

Note

  • A dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist; used as a protective agent in splanchnic artery occlusion shock.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H15-N3-O3

Molecular Weight

  • 285.302
 
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Names and Synonyms

Name of Substance

  • 3-Carbamyl-(3'-picolyl)-4-methoxy-1-benzamide

Synonyms

  • 3-Carbamyl-(3'-picolyl)-4-methoxy-1-benzamide
  • 4-Methoxy-N(sup 3)-(3-pyridinylmethyl)-1,3-benzenedicarboxamide
  • G 619

Systematic Names

  • 1,3-Benzenedicarboxamide, 4-methoxy-N(sup 3)-(3-pyridinylmethyl)-
  • 1,3-Benzenedicarboxamide, 4-methoxy-N3-(3-pyridinylmethyl)-

Registry Numbers

CAS Registry Number

  • 108828-56-4

System Generated Number

  • 0108828564

Structure Descriptors

InChI

1S/C15H15N3O3/c1-21-13-5-4-11(14(16)19)7-12(13)15(20)18-9-10-3-2-6-17-8-10/h2-8H,9H2,1H3,(H2,16,19)(H,18,20)

InChIKey

QWZWECXMQXZQOG-UHFFFAOYSA-N

Smiles

c1(cc(c(cc1)OC)C(=O)NCc1cnccc1)C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 463mg/kg (463mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA
Cardiovascular Drug Reviews. Vol. 11, Pg. 116, 1993.
mouse LD50 oral 1758mg/kg (1758mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Cardiovascular Drug Reviews. Vol. 11, Pg. 116, 1993.
mouse LD50 subcutaneous 966mg/kg (966mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Cardiovascular Drug Reviews. Vol. 11, Pg. 116, 1993.
rat LD50 intravenous 569mg/kg (569mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Cardiovascular Drug Reviews. Vol. 11, Pg. 116, 1993.
rat LD50 oral 1725mg/kg (1725mg/kg)   Cardiovascular Drug Reviews. Vol. 11, Pg. 116, 1993.
rat LD50 oral 1725mg/kg (1725mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Cardiovascular Drug Reviews. Vol. 11, Pg. 116, 1993.
rat LD50 subcutaneous 1326mg/kg (1326mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Cardiovascular Drug Reviews. Vol. 11, Pg. 116, 1993.